background: meiotic genes are very important candidates for genes contributing to female and male infertility. mammalian mutl homologues have dual roles in dna mismatch repair (mmr) after replication errors and meiotic reciprocal recombination. the mutl homologs, mlh1 and mlh3 , are crucial for meiotic reciprocal recombination and human fertility. in this study the functional polymorphisms of m...

Mutations at A/T bases within immunoglobulin genes have been shown to be generated by a repair pathway involving the DNA-binding moiety of the mismatch repair complex constituted by the MSH2-MSH6 proteins, together with DNA polymerase eta (pol eta). However, residual A/T mutagenesis is still observed upon inactivation in the mouse of each of these factors, suggesting that the panel of activitie...

Mismatch (MMR) repair system plays a significant role in restoration of stability in the genome. Mutations in mismatch repair genes hamper their activity thus bring about a defect in mismatch repair (MMR) mechanism thereby conferring instability in the microsatellite sequences of both the coding and non-coding regions of the genome. Mutated mismatch repair genes result in the expansion or contr...

background: hereditary non-polyposis colorectal cancer (hnpcc) is a common hereditary cancer predisposing syndrome has molecular and clinicopathological features still have remained ambiguous within iranian populations. we discuss in this article some molecular and clinicopathological features of the condition. methods: the study was a descriptive retrospective and designed on 1659 colorectal c...

Werner syndrome (WS) is an autosomal recessive disease, the phenotype of which is a caricature of premature aging. WS cells and cell lines display several types of genetic instability, and WS patients have an increased risk of developing cancer. The WS locus (WRN) encodes a protein that shows significant sequence homology to the RecQ family of DNA helicases. Because a DNA helicase may function ...