نتایج جستجو برای: mirwalk
تعداد نتایج: 77 فیلتر نتایج به سال:
MicroRNAs are small, non-coding RNA molecules that can complementarily bind to the mRNA 3'-UTR region to regulate the gene expression by transcriptional repression or induction of mRNA degradation. Increasing evidence suggests a new mechanism by which miRNAs may regulate target gene expression by binding in promoter and amino acid coding regions. Most of the existing databases on miRNAs are res...
Urothelial carcinoma of bladder (UCB) is a common urological malignancy in the world, but its progression mechanism remains unclear. MiR-612 was found as an anti-tumor factor multiple types cancer, while few studies have revealed functions UCB cells. Based on this, cells such HTB-9 and HTB-4, normal urothelial SV-Huc1, were used subjects this study. Western blot, qRTPCR, CCK-8 assay transwell t...
background: type 1 diabetes (t1d) is caused by cell-mediated autoimmune attack on pancreatic beta-cells. previous studies highlight the role of micrornas (mirnas) in the pathogenesis of t1d. mirnas are small non-coding rnas involved in the regulation of gene expression post-transcriptionally. in this work, mir-18b was chosen and the differential expression of it was measured between t1d patient...
BACKGROUND Upper tract urothelial carcinomas (UT-UC) can invade the pelvicalyceal system making differential diagnosis of the various histologically distinct renal cell carcinoma (RCC) subtypes and UT-UC, difficult. Correct diagnosis is critical for determining appropriate surgery and post-surgical treatments. We aimed to identify microRNA (miRNA) signatures that can accurately distinguish the ...
BACKGROUND The aim of this study was to screen the molecular targets of miR-34a in colorectal cancer (CRC) and construct the regulatory network, to gain more insights to the pathogenesis of CRC. MATERIAL AND METHODS The microarray data of CRC samples and normal samples (GSE4988), as well as CRC samples transformed with miR-34a and non-transfected CRC samples (GSE7754), were downloaded from the ...
Abstract In this study, we performed RNA sequencing of Prx II +/+ and ?/? dermal mesenchymal stem cells (DMSCs) to identify differentially expressed genes (DEGs). To explore the role in DMSCs, Gene Ontology analysis DEGs. The results showed that DEGs were mainly involved biological processes cell migration, intercellular adhesion, coordination regulation homing. Through construction protein–pro...
Gastric cancer (GC) is one of the leading causes of cancer-related deaths throughout China and worldwide. The discovery of microRNAs (miRNAs) has provided a new opportunity for developing diagnostic biomarkers and effective therapeutic targets in GC. By performing microarray analyses of benign and malignant gastric epithelial cell lines (HFE145, NCI-N87, MKN28, RF1, KATO III and RF48), 16 signi...
BackgroundIntramyocardial injection of heart explant-derived cells (EDCs) improves cardiac function in preclinical models ischemic cardiomyopathy. This therapeutic benefit is partially attributable to the anti-inflammatory cargo (micro RNAs and proteins) enriched within extracellular vesicles (EVs) released by EDCs. Recent work has shown that activation NLRP3 (NOD-, LRR- pyrin domain-containing...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید