BACKGROUND/AIMS Angiotensin converting enzyme 2 (ACE2) treatment suppresses the severity of acute lung injury (ALI). The effects of ACE2 in ALI have been shown to not only result from its antagonizing hydrolyzing angiotensin II (AngII), which is responsible for reduction in the vascular tension and pulmonary accumulation of inflammatory cells, but also result from a role of ACE2 in suppressing ...

Recent evidence showed that microRNA-7 (miR-7) played an important role in the pathologies of lung-related diseases. However, the potential role of miR-7 in acute lung injury (ALI) still remains poorly understood. Here, we assessed the effect of miR-7 deficiency on the pathology of ALI. We, first, found that the expression of miR-7 was upregulated in lung tissue in murine LPS-induced ALI model....

MicroRNA (miRNA) mediates RNA interference to regulate a variety of innate immune processes, but how miRNAs coordinate the mechanisms underlying acute lung injury/acute respiratory distress syndrome (ALI/ARDS) in patients with pulmonary inflammatory injury is still unknown. In this study, we demonstrated that miR-223 limits the number of Ly6G+ neutrophils and inhibits the activity of the NLRP3 ...

OBJECTIVE Acute lung injury (ALI) is a severe complication for patients undergoing cardiac surgery necessitating cardio-pulmonary bypass (CPB), however, the possible relationship between microRNAs change and ALI induced by CPB is still not completely understood. OBJECTIVE the aim of this study is to determine the microRNAs level changes in patients with ALI induced by CPB and its involved mec...

Severe combined immunodeficient (seid) C.B-17 mice are deficient in variable (diversity) joining region recombination, the process of assem bling the immunoglobulin and T-cell receptor genes from gene segments, thereby creating much of the enormous diversity of antigen-binding ca pacity, seid mice are also sensitive to ionizing radiation, as a result of their deficiency in double-strand break r...

Isoflurane alleviates the inflammatory response in endotoxin-induced acute lung injury (ALI). In this study, we investigated the protective mechanism of isoflurane postconditioning in lipopolysaccharide (LPS)induced ALI. Exposure to isoflurane decreased miR-155 and upregulated HIF-1 alpha and HO-1 mRNA and protein. The effects of isoflurane on HIF-1 alpha mRNA and protein could be inhibited by ...

The Institute of Medicine recently proposed a new case definition for chronic fatigue syndrome (CFS), as well as a new name, Systemic Exertion Intolerance Disease (SEID). Contrary to the Fukuda et al.'s CFS case definition, there are few exclusionary illnesses specified for this new SEID case definition. The current study explored this decision regarding exclusionary illnesses using the SEID cr...

Ali Meghdari, Seyyed Mohammad H. Lavasani, Mohsen Norouzi and Mir Saman Rahimi Mousavi Robotica / FirstView Article / May 2013, pp 1 ­ 11 DOI: 10.1017/S0263574713000362, Published online: 22 May 2013 Link to this article: http://journals.cambridge.org/abstract_S0263574713000362 How to cite this article: Ali Meghdari, Seyyed Mohammad H. Lavasani, Mohsen Norouzi and Mir Saman Rahimi Mousavi Minim...