نتایج جستجو برای: mir 103a 3p

تعداد نتایج: 49246  

Background: MiR-103a-3p is a small non-coding RNA and has been reported to be involved in osteogenic proliferation and differentiation, but the role of miR-103a-3p in human osteoarthritis (OA) remains unclear. Objectives: In this study, we aimed to explore its function and molecular target in chondrocytes during OA pathogenesis. Materials an...

2015
Da Sol Kim Sun Young Lee Jung Hee Lee Yong Chan Bae Jin Sup Jung

The elucidation of the molecular mechanisms underlying the differentiation and proliferation of human adipose tissue-derived stromal cells (hADSCs) represents a critical step in the development of hADSCs-based cellular therapies. To examine the role of the microRNA-103a-3p (miR-103a-3p) in hADSCs functions, miR-103a-3p mimics were transfected into hADSCs in order to overexpress miR-103a-3p. Ost...

2017
Vidyanand Anaparti Irene Smolik Xiaobo Meng Victor Spicer Neeloffer Mookherjee Hani El-Gabalawy

BACKGROUND Epigenetic mechanisms can integrate gene-environment interactions that mediate disease transition from preclinical to clinically overt rheumatoid arthritis (RA). To better understand their role, we evaluated microRNA (miRNA, miR) expression profile in indigenous North American patients with RA who were positive for anticitrullinated protein antibodies; their autoantibody-positive, as...

2014
Daniel G. Weber Swaantje Casjens Georg Johnen Oleksandr Bryk Irina Raiko Beate Pesch Jens Kollmeier Torsten T. Bauer Thomas Brüning

BACKGROUND For the detection of malignant mesothelioma no single biomarker with reasonable sensitivity and specificity has been described so far. Mesothelin, the most prominent blood-based biomarker, is characterized by high specificity but low sensitivity. It might be reasonable to combine biomarkers of different molecular classes in order to improve the overall performance. The aim of this st...

2016
Xiumei Jiang Lutao Du Weili Duan Rui Wang Keqiang Yan Lili Wang Juan Li Guixi Zheng Xin Zhang Yongmei Yang Chuanxin Wang

Noninvasive biomarkers for predicting the risk of muscle-invasive bladder cancer (MIBC) may expedite appropriate therapy and reduce morbidity and cost. Genome-wide miRNA analysis by Miseq sequencing followed by two phases of reverse transcription quantitative real-time PCR (RT-qPCR) assays were performed on serum from 207 MIBC patients, 285 nonmuscle-invasive bladder cancer (NMIBC) patients and...

2017
Tommaso Cavalleri Laura Angelici Chiara Favero Laura Dioni Carolina Mensi Claudia Bareggi Alessandro Palleschi Arianna Rimessi Dario Consonni Lorenzo Bordini Aldo Todaro Valentina Bollati Angela Cecilia Pesatori

BACKGROUND Malignant Pleural Mesothelioma (MPM) is an aggressive cancer mainly caused by asbestos exposure and refractory to current therapies. Specific diagnostic markers for early MPM diagnosis are needed. Changes in miRNA expression have been implicated in several diseases and cancers, including MPM. We examined if a specific miRNA signature in plasmatic extracellular vesicles (EV) may help ...

2018
Ye Chen SuNing Chen Jian Zhang YangMin Wang Zhengping Jia Xin Zhang Xiao Han Xiuquan Guo XiaoDi Sun Chen Shao Ji Wang Tian Lan

The current study aimed to identify a comprehensive expression-profile of microRNAs (miRNAs) in expressed prostatic secretion (EPS) collected from healthy men and patients with CP/CPPS (Chronic prostatitis/Chronic pelvic pain syndrome). After clinical screening of 382 participants, 60 healthy men and 59 IIIA CP/CPPS patients with significant pelvic-pain were included into this study from March ...

Journal: :Neoplasma 2021

MicroRNA (miR)-103a-3p has been shown to be involved in the development and progression of several types cancer. However, role miR-103a-3p thyroid cancer remains unclear. This study investigated effects on biological characteristics cells related mechanisms. In present study, we found that expression was increased tissues compared non-cancerous tissues. Additionally, cell lines (TPC-1, SW579, B...

2016
Jeremy T-H. Chang Fan Wang William Chapin R. Stephanie Huang

Breast cancer is the second-most common cancer and second-leading cause of cancer mortality in American women. The dysregulation of microRNAs (miRNAs) plays a key role in almost all cancers, including breast cancer. We comprehensively analyzed miRNA expression, global gene expression, and patient survival from the Cancer Genomes Atlas (TCGA) to identify clinically relevant miRNAs and their pote...

2017
Wan-Sheng Chang Yong-Hong Wang Xiao-Tun Zhu Chuan-Jie Wu

BACKGROUND Our study aimed to identify key differentially expressed genes (DEGs) and miRNAs (DEmiRNAs) which can serve as potential biomarkers for diagnosis and therapy of Alzheimer's disease (AD). MATERIAL AND METHODS We performed miRNA and mRNA integrated analysis (MMIA) to identify DEGs and DEmiRNAs of AD. The AD-specific DEmiRNAs-targets interaction network was contrasted. Gene ontology (GO...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید