When cells of the Walker 256 rat tumor were incu bated in vitro with neuraminidase, free sialic acid accu mulated in the medium without detectable loss of tumor cell viability, as indicated by the unchanged survival of rats given i.p. injections of 50, 100, or 250 cells. For de termination of the effect of neuraminidase treatment of the tumor cells on their adherence to living mesothelium, 1 te...

biological effects extracorporeal shock wave lithotripsy (eswl) is not precisely known. we have evaluated two urinary enzymes activity n-acetyl-b-d-glucosamine (nag) and alanine amino peptidase (aap) before and after unilateral eswl as markers for renal parenchymal damage. forty eight patients with kidney stones (mean age 39) who had presented for the first time or at least one year after their...

AIM To determine whether urinary beta 2-glycoprotein-1 assays can provide improved discrimination between chronic renal diseases which are primarily of tubular or glomerular origin. METHODS Urinary beta 2-glycoprotein-1, retinol-binding protein, alpha 1-microglobulin, beta 2-microglobulin, N-acetyl-beta-D-glucosa-minidase and albumin were measured in 51 patients with primary glomerular diseas...

Langer (1) reported that external to the lipid bilayer or unit membrane at the surface of the myocardial cell is the glycocalyx which is composed of two layers, the surface coat and the external lamina. Both layers contain abundant fixed negatively charged sites which are due in part to the presence of sialic acid in the glycocalyx. Although several investi gators have studied the pharmacologic...