A B S T R A C T Parameters of mineral and bone metabolism were studied in 17 patients treated chronically with supraphysiologic doses of glucocorticoids. When compared to 15 matched normal subjects, the patient group exhibited similar serum 25-hydroxyvitamin D (25-OHD) levels, decreased intestinal 47Ca absorption, increased serum immunoreactive parathyroid hormone, and decreased forearm bone ma...

Background: Evidence suggests that vitamin D status in adults is positively associated with calcium absorption fraction and inversely associated with serum PTH. The objective of this study was to evaluate the relationships among vitamin D status, PTH, and calcium absorption in midpubertal boys and girls. Methods: Calcium absorption was measured by using a stable isotope method in 93 young adole...

A. M. Frantz. Ass. Res. nerv. Dis. Proc., vol. II. Williams and Wilkins, Baltimore. Jesse, J. H. (1867). Memoirs of the Life and Reign of King George the Third, vol. 3. Tinsley, London. Jones, R. (1789). An Enquiry into the Nature, Causes, and Termination of Nervous Fevers; together with Observations tending to illustrate the Method of Restoring His Majesty to Health, and of preventing Relapses...

Inorganic elements (metals, non-metals, transition elements, and electrolytes commonly called “minerals” in nutrition science) are critical to all life processes as enzyme cofactors, stabilizers of proteins, structural components of tissues, second messengers, regulators of acid-base balance, participants in redox reactions, and for the maintenance of cellular electrical potential. For this rea...

Mineral metabolism in the mother must adapt to the demand created by the fetus and placenta, which together draw calcium and other minerals from the maternal circulation to mineralize the developing fetal skeleton. Similarly, mineral metabolism must adapt in the lactating woman to supply sufficient calcium to milk and the suckling neonate. Potential adaptations include increased intake of miner...

Although less frequent than vascular calcification, cardiac valve calcification (CVC) is a relevant clinical problem affecting about 2%-10% of adults from the general population aged 75 years and older, and is 5- to 10-fold more prevalent in individuals with impaired kidney function. An expanding body of evidence suggests that mineral metabolism abnormalities aside from traditional cardiovascul...