Abstract   Introduction: It is demonstrated that the degree of clinical improvement in   Parkinson's disease (PD) achieved by deep brain stimulation (DBS) is largely dependent   on the accuracy of lead placement. In addition, individual variability in the   situation of subthalamic nucleus (STN) is responsible for spatial inter-individual   fluctuations of the real patient's target.   Objecti...

abstract introduction: it is demonstrated that the degree of clinical improvement in parkinson's disease (pd) achieved by deep brain stimulation (dbs) is largely dependent on the accuracy of lead placement. in addition, individual variability in the situation of subthalamic nucleus (stn) is responsible for spatial inter-individual fluctuations of the real patient's target. objective: our study ...

abstract   introduction: it is demonstrated that the degree of clinical improvement in   parkinson's disease (pd) achieved by deep brain stimulation (dbs) is largely dependent   on the accuracy of lead placement. in addition, individual variability in the   situation of subthalamic nucleus (stn) is responsible for spatial inter-individual   fluctuations of the real patient's target.  ...

OBJECT The authors sought to determine the location of deep brain stimulation (DBS) electrodes that were most effective in treating Parkinson disease (PD). METHODS Fifty-four DBS electrodes were localized in and adjacent to the subthalamic nucleus (STN) postoperatively by using magnetic resonance (MR) imaging in a series of 29 patients in whom electrodes were implanted for the treatment of me...

OBJECTIVE To describe the results of deep brain stimulation of the ipsilateral posterior hypothalamus for the treatment of drug-resistant chronic cluster headaches (CHs). A technique for electrode placement is reported. METHODS Because recent functional studies suggested hypothalamic dysfunction as the cause of CH bouts, we explored the therapeutic effectiveness of posterior hypothalamic stim...

PURPOSE Stereotactic pallidotomy, which has evolved as a result of technological advances in high-resolution MR imaging and microelectrode electrophysiological recording, is becoming a major form of treatment for patients with Parkinson disease in whom medical therapy has failed. We describe the location and appearance of the pallidotomy lesion on high-resolution MR images. METHODS MR images ...

We investigate the multicritical behavior of three-dimensional Z_2 gauge Higgs model, at point (MCP) its phase diagram, where one first-order transition line and two continuous Ising-like lines meet. The duality properties model determine some features MCP located along self-dual line. Moreover, we argue that system develops a XY MCP, which is controlled by stable fixed Landau-Ginzburg-Wilson f...

The classical PERT approach uses the path with the largest expected duration as the critical path to estimate the probability of completing a network by a given deadline. However, in general, such a path is not the most critical path (MCP) and does not have the smallest estimate for the probability of completion time. The main idea of this paper is derived from the domination structure between ...

MOTIVATION We introduce a dual multiple change-point (MCP) model for recombination detection among aligned nucleotide sequences. The dual MCP model is an extension of the model introduced previously by Suchard and co-workers. In the original single MCP model, one change-point process is used to model spatial phylogenetic variation. Here, we show that using two change-point processes, one for sp...

Monocyte chemoattractant protein-1 (MCP-1) mediates monocyte migration into tissues in inflammatory diseases and atherosclerosis. We have investigated structure-activity relationships for human MCP-1. Mutations were introduced based upon differences between MCP-1 and the structurally related but functionally distinct molecule interleukin-8 (IL-8). Mutant proteins produced using the baculovirus/...