Microtubules, the active filaments with tubular shapes, play important roles in a wide range of cellular functions, including structural supports, mitosis, cytokinesis, and vesicular transport, which are essential for the growth and division of eukaryotic cells. Finding properties of microtubules is one of the main concerns of scientists. This work helps to obtain mechanical properties of m...

The DNA structure checkpoint protein Rad26ATRIP is also required for an interphase microtubule damage response. This checkpoint delays spindle pole body separation and entry into mitosis following treatment of cells with microtubule poisons. This checkpoint requires cytoplasmic Rad26ATRIP, which is compromised by the rad26:4A allele that inhibits cytoplasmic accum...

objective(s):emap-like protein 5 (eml5) is a new echinoderm microtubule-associated protein that is expressed in the central nervous system. the aim of this study was to investigate the expression profile of eml5 in the anterior temporal neocortex of patients presenting with intractable epilepsy (ie). materials and methods:western blot assays were performed to determine eml5 expression in 36 sur...

microtubules, the active filaments with tubular shapes, play important roles in a wide range of cellular functions, including structural supports, mitosis, cytokinesis, and vesicular transport, which are essential for the growth and division of eukaryotic cells. finding properties of microtubules is one of the main concerns of scientists. this work helps to obtain mechanical properties of micro...

This work is conducted to obtain mechanical properties of microtubule. For this aim, interaction energy in alpha-beta, beta-alpha, alpha-alpha, and beta-beta dimers was calculated using the molecular dynamic simulation. Force-distance diagrams for these dimers were obtained using the relation between potential energy and force. Afterwards, instead of each tubulin, one sphere with 55 KDa weight ...

In article number 2000985, Marek Piliarik and co-workers develop a new light microscopy technique for label-free detection localization of conformation changes subsequent depolymerization tubulin segments from tip disassembling microtubule. High-speed imaging the transient structural fluctuations suggests stochastic mechanism microtubule dynamic instability.

background: microtubules (mt) are important components of cell cytoskeleton and play key roles in cell motility mitosis and meiosis. they are also the targets of several anticancer agents which indicating their importance in maintaining cell viability. microtubular reorganization contributing to apoptotic morphology occurs in normal and neoplastic cells undergoing apoptosis induced by cytotoxic...

In this paper, vibration of the protein microtubule, one of the most important intracellular elements serving as one of the common components among nanotechnology, biotechnology and mechanics, is investigated using stress and strain gradient elasticity theory and orthotropic elastic shells model. Microtubules in the cell are influenced by internal and external stimulation and play a part in con...

The microtubule-associated protein, doublecortin-like kinase 1 (DCLK1), is highly expressed in a range of cancers and prominent therapeutic target for inhibitors. physiological roles DCLK1 activity how it regulated remain elusive. Here, we analyze the role mammalian regulating microtubule binding. We found that autophosphorylates residue within its C-terminal tail to restrict prevent aberrant h...

Abstract Cells can position multiple copies of components like carboxysomes, nucleoids, and nuclei at regular intervals. By controlling positions, cells, for example, ensure equal partitioning organelles over daughter cells and, in the case nuclei, control cell sizes during cellularization. Mechanisms that generate patterns are as yet poorly understood. We used fission yeast cycle mutants to in...