background: occupational and environmental exposures mostly represent complex mixture of genotoxic agents, however there is a wide variation in the specificity of biomarkers. exploration of correlations among biomarkers contributes to the further progress of molecular cancer epidemiology and to the selection of the optimal biomarkers for the investigation of human exposure to carcinogens. the a...

---・-A micronucleus test using BDFi male mice was conducted in order to evaluate the in vive mutagenicity of mofezolac (N-22). N-22 was orally administered at doses of 75, 150, 300 arid 600 mglkg, with a sampling time of 24 hr. The frequency of polychromatic erythrocytes with micronuclei was O,07-O,08% in the groups treated with N-22 and did not differ markedly from that of the vehicle control ...

As part of a larger literature study on transgenic animals in mutagenicity testing, test results from the transgenic mutagenicity assays (lacI model; commercially available as the Big Blue(R) mouse, and the lacZ model; commercially available as the Mutatrade markMouse), were compared with the results on the same substances in the more traditional mouse bone marrow micronucleus test. 39 substanc...

crude oil is enriched in polycyclic aromatic hydrocarbons (pahs). many pah analogs have proved to potentially damage dna. dna damage can be assessed using various biomarkers to find out the degree of genotoxicity of pollutants following in vitro exposure. in this research the comet assay and micronucleus (mn) test were used to detect dna damages and cytogenetic changes following crude oil expos...

Municipal wastewaters may contain a variety of genotoxic compounds, including drugs or their metabolites, PAHs, etc. Bacterial genotoxicity assays use DNA impairment as end point while micronucleus tests, conducted on eucaryotes, assess chromosome aberrations. As relatively few comparative studies exist, in this study results of the micronucleus test using the painter’s mussel (Unio pictorum) a...

Studies on the micronucleus test in Vicia faba root tips (VM test) were carried out in order to estimate the effects at low doses of X-rays (1, 2, 4, 8 and 12 R). The control value of micronucleus frequency is about 0.44/1000 cells. The dose where the micronucleus frequency is twice that of the control was estimated at 1.384 R. There was a linear kinetic dose response for the low-dose range stu...

background: there is unprecedented increase in the processing and packaging of many plant materials into food supplements, herbal medicine, skincare and cosmetic products for human needs. baphia nitida is used for topical skincare products. toluene, a toxic aromatic solvent, is increasingly being used in the production of these skincare and cosmetic products in many industries. this study asses...

BACKGROUND Comet assay and micronucleus test have been used increasingly to evaluate the genotoxicity of many metals and their organic compounds in aquatic ecosystems. The use of endemic aquatic organisms as biological sentinels has proved useful in environmental monitoring. In this study, the genetic damage caused by methylmercury (MeHg) in Aequidens tetramerus (commonly called acará-sela) was...