نتایج جستجو برای: micronucleus

تعداد نتایج: 2330  

Journal: :Medycyna Weterynaryjna 2022

Cytochalasine B is an indicator in the CBMN assay, but can also be geno- or cytotoxic. The aim of study was to determine optimal dose cytochalasine for Cytokinesis-Block Micronucleus (CBMN) assay domestic cat. results revealed a surprisingly high number micronuclei (MN) relation doses used. It found that concentration 2.5 μg/ml enough obtain binuclear cells, with minimal toxic effect on lymphoc...

2006
B. R. SESHACHAR

The reorganization of the macronucleus from the vegetative micronucleus is described in Epistylis articulata (Ciliophora, Peritricha). Individuals which have accidentally been deprived of a macronucleus during binary fission develop a new one from the micronucleus. In such amacronucleate animals, the micronucleus divides into two, one of them growing into a macronucleus, the other remaining as ...

2012
Afide Öcal Halil Erhan Eroğlu

Hypericum species, growing wild in Anatolia, widely used in traditional medicine in Turkey. In order to determine the genotoxic effect of Hypericum heterophyllum, human lymphocytes were incubated with the aqueous extracts. The increasing extract concentrations of Hypericum heterophyllum induced micronucleus. The rise of micronucleus shows that Hypericum heterophyllum at high concentrations may ...

Journal: : 2023

EVALUATION OF THE PROTECTIVE ROLE HYDROALCOHOLIC EXTRACT GINGER AND N-ACETYLCYSTEINE ON GENETIC DISORDER CAUSED BY SODIUM AZIDE HUMAN BLOOD LYMPHOCYTES MICRONUCLEUS METHOD

2015
Malinee Pongsavee

Sodium benzoate is food preservative that inhibits microbial growth. The effects of sodium benzoate preservative on micronucleus induction, chromosome break, and Ala40Thr superoxide dismutase gene mutation in lymphocytes were studied. Sodium benzoate concentrations of 0.5, 1.0, 1.5, and 2.0 mg/mL were treated in lymphocyte cell line for 24 and 48 hrs, respectively. Micronucleus test, standard c...

Journal: :The Journal of Cell Biology 1970
Kuruganti G. Murti David M. Prescott

The presence of RNA in the micronucleus of Tetrahymena pyriformis was detected by electron microscope radioautography after incubation with tritiated precursors. The specificity of RNA labeling was shown by ribonuclease digestion. The period of appearance of labeled RNA in the micronucleus is approximately coincident with the DNA synthesis period for the micronucleus. Pulse-chase experiments sh...

Journal: :Environmental Health Perspectives 1993
J Bérces M Otos S Szirmai C Crane-Uruena G J Köteles

The lymphocyte micronucleus assay was used to measure the average frequency of micronuclei in a population and thus assess genotoxic effects. Data from 174 persons give an average value of 16.4 +/- 7.3, and a slight age-dependence was observed. To detect combined environmental mutagen injuries the micronucleus assay was used to study the effects of metal compounds. Cadmium ions increased the mi...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006
Micheline Kirsch-Volders Raluca Antonina Mateuca Mathieu Roelants Annie Tremp Errol Zeiger Stefano Bonassi Nina Holland Wushou Peter Chang Peter Vande Aka Marlies Deboeck Lode Godderis Vincent Haufroid Hitoshi Ishikawa Blanca Laffon Ricardo Marcos Lucia Migliore Hannu Norppa Joao Paulo Teixeira Andrea Zijno Michael Fenech

The influence of genetic polymorphisms in GSTM1 and GSTT1 genes on micronucleus frequencies in human peripheral blood lymphocytes was assessed through a pooled analysis of data from seven laboratories that did biomonitoring studies using the in vivo cytokinesis-block micronucleus assay. A total of 301 nonoccupationally exposed individuals (207 males and 94 females) and 343 workers (237 males an...

Journal: :Journal of Carcinogenesis 2005
U Wahnschaffe A Bitsch J Kielhorn I Mangelsdorf

As part of a larger literature study on transgenic animals in mutagenicity testing, test results from the transgenic mutagenicity assays (lacI model; commercially available as the Big Blue(R) mouse, and the lacZ model; commercially available as the Mutatrade markMouse), were compared with the results on the same substances in the more traditional mouse bone marrow micronucleus test. 39 substanc...

Waterpipe Tobacco Smoke(WTS) is an unhealthy life style that may increase the risk of genotoxic responses and chronic diseases such as cancer. Micronucleus test is a successful and reliable method which is used for screening of genetotoxic responses of whole body and also for screening those people who had already exposed to genotoxic compounds. In this study, specific questionnaires were desig...

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