Machine-pulled high-impedance glass capillary microelectrode is standard for transmembrane potential (TMP) recordings. However, it is fragile and difficult to impale, especially in beating myocardial tissues. We hypothesize that a high-impedance pure iridium metal electrode can be used as an alternative to the glass microelectrode for TMP recording. The TMPs were simultaneously recorded from is...

Microelectrode Arrays In article number 2201716 by Matthew W. Kay, Luyao Lu, and co-workers, a microelectrode array (MEA) is laminated on the heart to show its stretchability. Another stretched MEA placed in light path capability for co-localized optical mapping. Green represents stimulation light. Yellow red lights represent resulting calcium voltage fluorescence while blue electrical signals ...

Microelectrode surfaces covered with nanostructures derived from components of extracellular matrix, such as collagen fibers, have shown immense beneficial effects in promoting neuronal growth and cellular signaling. Synthetic mimicking the features biological durable conductive materials could promote cell adhesion on microelectrode by providing topographical cues simultaneously improve charge...

Deep brain stimulation of the subthalamic nucleus is the standard of care for treating medically intractable Parkinson's disease. Although the adjunct of microelectrode recording improves the targeting accuracy of subthalamic nucleus deep brain stimulation in comparison with image guidance alone, there has been no investigation of the financial cost of intraoperative microelectrode recording. T...

Several variations of microelectrode arrays are used to record and stimulate intracortical neuronal activity. Bypassing the immune response to maintain a stable recording interface remains a challenge. Companies and researchers are continuously altering the material compositions and geometries of the arrays in order to discover a combination that allows for a chronic and stable electrode-tissue...

The development of implantable devices which enable fully wireless transmission of brain signals, recorded by microelectrode arrays (MEA) as dynamical neural circuit information, is one important goal for advancing human neuroprostheses. Current brain sensing research for prostheses via first clinical trials is offering tantalizing glimpses for the future, even if these technologies are cumbers...

A microfluidic device integrated with 3D thin film microelectrode arrays wrapped around serpentine-shaped microchannel walls has been designed, fabricated and tested for cell electrofusion. Each microelectrode array has 1015 discrete microelectrodes patterned on each side wall, and the adjacent microelectrodes are separated by coplanar dielectric channel wall. The device was tested to electrofu...

In this paper, a novel dual-sided microelectrode array is specially designed and fabricated for a rat Parkinson's disease (PD) model to study the mechanisms of deep brain stimulation (DBS). The fabricated microelectrode array can stimulate the subthalamic nucleus and simultaneously record electrophysiological information from multiple nuclei of the basal ganglia system. The fabricated microelec...