systemic antibiotics and locally applied antimicrobial agents have been suggested to enhance clinical parameters. patients exhibiting aggressive periodontitis in particular benefit from adjunctive antibiotic therapy. the purpose of this investigation was to evaluate the effect of local antibiotic therapy with metronidazole adjunctively to scaling and root planning (srp) in the treatment of aggr...

AIM To investigate the prevalence of Porphyromonas gingivalis in root canals of infected teeth with periapical abscesses and to investigate the antimicrobial susceptibility of this species to some frequently prescribed antibiotics. METHODOLOGY Samples were obtained from 70 root canals of abscessed teeth. Microbial sampling, isolation and bacterial identification were accomplished using approp...

background. the most common species isolated from primary endodontic infections are black-pigmented bacteria. these species are implicated in apical abscess formation due to their proteolytic activity and are fastidious in nature. therefore, the present study was carried out to evaluate the presence and identification of various pigmented porphyromonas and prevotella species in the infected roo...

the plant salvadora persica is used for oral hygiene in many parts of the world. it has been suggested that it has antibacterial properties, in addition to its ability to mechanically remove plaques. the aim of this study was to assess the antimicrobial activity of the herbal product persica containing salvadora persica against periodontopathogens porphyromonas gingivalis and aggregatibacter ac...

Background: The relationship between rheumatoid arthritis and poor oral hygiene has longbeen proven. Colonization of Porphyromonas gingivalis in the oral cavity can play an important role in rheumatoid arthritis. The aim of this study was to determine whether there is a relationship between rheumatoid arthritis disease and the presence of P. gingivalis. <stro...

Porphyromonas gingivalis produces proteases capable of degrading cytokines, host heme proteins and some antimicrobial peptides. In this study, we show that P. gingivalis culture supernatants fully or partially degrade human neutrophil peptide alpha-defensins and human beta-defensins after 30 min. This observation suggests that proteases from P. gingivalis degrade defensins and this activity cou...

Methanethiol (methyl mercaptan) is an important contributor to oral malodour and periodontal tissue destruction. Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum are key oral microbial species that produce methanethiol via methionine gamma lyase (mgl) activity. The aim of this study was to compare an mgl knockout strain of P. gingivalis with its wild type using a 10-s...

Porphyromonas gingivalis and Treponema denticola are periodontal pathogens that express virulence factors associated with the pathogenesis of periodontitis. In this paper we tested the hypothesis that P. gingivalis and T. denticola are synergistic in terms of virulence; using a model of mixed microbial infection in rats. Groups of rats were orally infected with either P. gingivalis or T. dentic...

The oral bacterium Porphyromonas gingivalis has special nutrient requirements due to its asaccharolytic nature subsisting on small peptides cleaved from host proteins. Using proteases and other virulence factors, P. gingivalis thrives as a component of a polymicrobial community in nutritionally favorable inflammatory environments. In this regard, P. gingivalis has a number of strategies that su...

The image for Fig 3 is missing Fig 3B and 3C. Please see the corrected Fig 3 here. Table 1 has been corrected for improved readability. Please see the corrected Table 1 here. Copyright: © 2015 Barbosa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provide...