An innovative, simple, economic, selective and sensitive of the stability indicating gradient reverse phase high performance liquid chromatography (RP-HPLC) method has been developed and validated for the analysis of assay of Miconazole nitrate and Benzoic acid and related substances of Miconazole nitrate in gel dosage form with better precision and accuracy. Miconazole nitrate & Benzioc acid a...

BACKGROUND Oral candidiasis (OC) is a common oral fungal infection. Recently, miconazole mucoadhesive tablets have been gaining attention for OC treatment. Despite trials in patients with human immunodeficiency virus and cancer, evidence of its application in the large-scale, general population with OC is lacking. This study aimed to evaluate the efficacy and safety of miconazole nitrate mucoad...

Diaper dermatitis (DD) complicated by candidiasis is a common problem in diaper-wearing infants and children. We report a double-blind, vehicle-controlled, parallel-group study evaluating the efficacy and safety of a low concentration of miconazole nitrate in a zinc oxide/petrolatum ointment for the treatment of DD complicated by candidiasis. Patients (N=330) who had DD with a severity score of...

Miconazole nitrate is an imidazole derivative antifungal agent, developed by Janssen Pharmaceutica, commonly applied topically to the skin or to mucous membranes to cure fungal infections. Over 90% of miconazole nitrate is reported to be bound to plasma proteins. In this study, miconazole nitrate was formulated into bioadhesive vaginal suppositories using different suppository bases such as fat...

Comparative efficacy of miconazole nitrate, graphite, Thuja and Chrysorobin ointments was assessed against three keratinophillic fungi, viz., Trichophyton terrestris, Chrysosporium tropicum and Microsporum gypseum. All the test fungi were sensitive to the anti microbials tested in the present study. Miconazole nitrate, showed the maximum activity followed by Graphite, and Thuja, whereas the min...

AIMS Miconazole is a synthetic imidazole antifungal that has a broad spectrum of activity against Candida albicans and non-albicans Candida species. The aim of this study was to evaluate the efficacy and safety of miconazole nitrate vaginal suppository and oral fluconazole in treating severe vulvovaginal candidiasis (SVVC). METHODS In this prospective, randomized case control study, 577 cases...

The goal of the present investigation is formulation and evaluation of a mucoadhesive gel for buccal delivery after solubility enhancement of very slightly water-soluble drug Miconazole Nitrate. Miconazole Nitrate is imidazole derivative useful in treatment of oropharyngeal Candidiasis, the most common infection in AIDS patients. The method namely solvent deposition with inclusion complex, soli...

The MICs and minimal lethal concentrations of four antimycotics, amphotericin B, 5-fluorocytosine, miconazole nitrate, and ketoconazole, were determined for 25 yeast isolates representing species uncommonly implicated in candidiasis. A microdilution procedure was employed with complex and synthetic media. The isolates, in general, were susceptible to the same antimicrobial agents shown to be ef...

In a single blind trial, a three day course of butoconazole nitrate cream was compared with a seven day course of miconazole nitrate cream, both applied intravaginally, in treating vaginal candidiasis. They were equally effective. The cure rate for patients treated with butoconazole was 82.8% at the first follow up (a mean of 18.4 days from the beginning of the treatment) and 76.7% at second fo...

In a multicenter, randomized, invesgtigator-blind, parallel study, 398 patients were dispensed topical butoconazole nitrate 2% cream for 3 days (n = 199) or miconazole nitrate 2% cream for 7 days (n = 199) for vaginal use. Efficacy analyses included 254 patients with culture-confirmed Candida (119 butoconazole and 135 miconazole users). Of the 398 patients issued study medication, 9 were lost t...