The proteasome inhibitor bortezomib (Velcade®) was recently approved for the treatment of therapy-refractive multiple myeloma and is under investigation for numerous other types of cancer. A phase I clinical trial in paediatric patients resulted in tolerable toxicity. Since the emergence of chemoresistance represents one of the major drawbacks in cancer therapy, we investigated the influence of...

Direct electrochemistry of glucose oxidase (GOD) was achieved when an ionic liquid/GOD-Polyhydroxy-C60 functional membrane was confined on a glassy carbon electrode (GCE). The cyclic voltammograms (CVs) of the modified GCE showed a pair of redox peaks with a formal potential (E°') of - 329 ± 2 mV. The heterogeneous electron transfer constant (k(s)) was 1.43 s-1. The modified GCE response to glu...

The temperature dependence of the rate constant for substrate oxidation by the dehaloperoxidase-hemoglobin (DHP) of Amphitrite ornata has been measured from 278 to 308 K. The rate constant is observed to increase over this range by approximately a factor of 2 for each 10 °C temperature increment. An analysis of the initial rates using a phenomenological approach that expresses the peroxidase pi...

a simple mathematical model of steady state  oxygen distribution subject to diffusive transport and non- linear uptake in a retinal cylinder has been developed. the approximate analytical solution to a reaction- diffusion equation are obtained by using series expansions. the computational results for the scaled variables are presented through graphs. the effect of the important parameters (1) d...

A mathematical model of reaction-diffusion problem with Michaelis-Menten kinetics in catalyst particles arbitrary shape is investigated. Analytical expressions the concentration substrates are derived as functions Thiele modulus, modified Sherwood number, and Michaelis constant. Taylor series approach Akbari-Ganji's method utilized to determine substrate effectiveness factor. The effects factor...