background there is still no suitable mice model that can completely mimic the human fulminant hepatitis, which sets a block for drug effect evaluation and mechanism researching of human fulminant hepatitis. objectives the aim of this study was to establish an animal model able to mimic the main features of human fulminant hepatitis. materials and methods dimethylnitrosamine (dmn) was peritonea...

introduction dendritic cells (dcs) are bone marrow-derived cells, which migrate to lymphoid and non-lymphoid organs via blood. liver dcs are believed to play an important role in the regulation of hepatic allograft acceptance. however, because of inherent difficulties in isolating adequate numbers of dcs from liver, limited information is available on the phenotype and functions of liver dcs. t...

protective action of ficus carica leaf ethanolic extract (obtained by maceration) was evaluated in an animal model of hepatotoxicity induced by carbon tetrachloride (ccl4). male albino mice were divided into six groups. group i was normal control group; group ii received olive oil (ccl4 solvent), groups iii-vi received ccl4. after inducing hepatic damage, group iii served as control for ccl4; a...

background: the present study was carried out to investigate the possible protective effects of royal jelly (rj) on oxymetholone (oxm)-induced oxidative liver injuries in mice. methods: in total, 32 adult male nmri mice were divided into four groups of eight mice each. mice in groups 1 and 2 were orally administered 5 mg/kg/day oxm for 30 days. at the same time, mice in group 3 received rj at a...

background and objectives: acrylamide is a monomer which is formed in foodstuffs containing carbohydrates altered to asparagine during thermal processing. vitamin e is a component in human diet considered as the most effective lipid-soluble antioxidant found in the biological system. it prevents initiation of oxidative tissue damage. the aim of this study was to investigate the potential role o...

background: the radioprotective effect of grewia asiatica fruit (gae) which contains anthocyanin type cyanidin 3- glucoside, vitamin c, a, minerals, carotenes and dietary fibers etc was studied. materials and methods: for study swiss albino mice were divided into five groups-1. control (vehicle treated) 2. gae treated (700 mg / kg. b.wt / day for fifteen days), 3. irradiated (5 gy), 4. gae + ir...

objective(s) quinazolinones are heterocyclic compounds, with biological and pharmacological activities, such as inhibiting some proteins, enzymes and reducing blood lipids. materials and methods following previous results of our group, effects of two new derivatives of quinazolinones 9(3)-quinazolinone-2-propyl-2-phenylethyl (qppe) and 9(3)-quinazolinone-2-ethyl-2-phenylethyl (qepe) on livers, ...

dendritic cells (dcs) play an important role in induction of cellular immune responses. it seems that dcs that reside in different organs may be distinct in their ability to  induce immune responses. this study was done to address the differences between spleen and liver dcs in induction of immune response and/or tolerance. cd11c+  dcs were separated from the liver and spleen of c57bl/6 mice an...

background: this study was carried out to observe the radioprotective effects of rosemarinus officinalis leaves extract (roe) against radiation-induced histopathological alterations in liver of mice. materials and methods: adult swiss albino mice were exposed to 6 gy gamma radiation in the presence (experimental) or absence (control) of roe to study the qualitative and quantitative alterations ...

carbosulfan (2,3-dihydro-2,2dimethyl-7-benzofuronyl [(dibutyl amino) thio] methyl] a carbamate insecticide and acaricide was administered orally at an effective dose of 48 mg/kg/day to albino mice for 5, 10, 20 and 30 days .control mice received similar quantities of olive oil. daily body weights were recorded and mice were sacrificed after 24 hours after the terminal exposure. the histologic e...