linarin is a flavone glycoside in the plants flos chrysanthemi indici, buddleja officinalis, cirsium setosum, mentha arvensis and buddleja davidii, and has been reported to possess analgesic, antipyretic, anti-inflammatory and neuroprotective activities. in this paper, linarin was investigated for its ache inhibitory potential both in vitro and ex vivo. ellman’s colorimetric method was used for...

objective(s):there are supportive evidences about the possible role of latent toxoplasma. gondii infections on the behavior and neurologic functions, such as increased dopamine levels in the brain. the aim of this study was to examine anti-toxoplasma activity of aripiprazole that is an atypical anti-psychotic drug in mice. materials and methods: mice were randomly divided into four groups, incl...

Objective(s):There are supportive evidences about the possible role of latent Toxoplasma. gondii infections on the behavior and neurologic functions, such as increased dopamine levels in the brain. The aim of this study was to examine anti-toxoplasma activity of aripiprazole that is an atypical anti-psychotic drug in mice. Materials and Methods: Mice were randomly divided into four groups, inc...

background : toxoplasma gondii is an obligate intracellular parasite that infects humans at high preva-lence rates. the virulent rh strain of t. gondii is generally considered to have lost its cyst forming ca-pacity. this study performed to obtain tissue cysts in mice infected with tachyzoites of rh strain treated with sulfadiazine (sdz). it provides the opportunity to analyze the conversion of...

miconazole is an imidazole antifungal agent, commonly applied topically to the skin or mucous membranes. the aim of this study was to examine the alternative method for gaining mechanism or the bimolecular changes caused by the possible teratogenic effects of miconazole on mice fetus brain tissue using ftir-microspectroscopy. the mice were injected with miconazole (60 mg/kg) on gestation day 9....

background: toxoplasma gondii is the most common parasite causing latent cerebral infections in human. it has been shown that some anti-psychotic drugs are able to inhibit the proliferation of the parasite in in vitro study. there is very limited data regarding the inhibitory effect of anti-psychotics on toxoplasma in in vivo . in this study, we evaluated anti- toxoplasma activity of fluphenazi...

introduction: survivin, an inhibitor of apoptosis (iap) containing one baculoviral iap repeat (bir) domain, has been reported to be able to regulate both cellular proliferation and apoptotic cell death. in the present study, we evaluated the differential expression of different variants of survivin during prenatal and postnatal development of brain in mice. material and methods a total of 27 nm...

Objective(s): In the present study, C57BL/6 female mice (n=56) were used to explore the neuroprotective effects of riboflavin in motor disability of experimental autoimmune encephalomyelitis (EAE) as a model of multiple sclerosis. Materials and Methods: The animals were assigned into 7 groups: sham-operated 1 (SO1), healthy mice receiving PBS (phosphate buffer saline); sham-operated 2 (SO2), h...

background: the aim of this study was to apply the nested-pcr and bioassay methods in detection and genotyping of toxoplasma gondii infection in provided sheep aborted fetus samples from qazvin province of iran. methods : eighteen sheep aborted fetal samples were studied by nested-pcr-rflp, histopathologi­cal observation and microbiological assay. bioassay in mice was carried out by inoculating...

Miconazole is an imidazole antifungal agent, commonly applied topically to the skin or mucous membranes. The aim of this study was to examine the alternative method for gaining mechanism or the bimolecular changes caused by the possible teratogenic effects of Miconazole on mice fetus brain tissue using FTIR-Microspectroscopy. The mice were injected with Miconazole (60 mg/Kg) on gestation day 9....