نتایج جستجو برای: metronomic chemotherapy

تعداد نتایج: 114478  

2016
M. Souto

Purpose: Low-dose metronomic chemotherapy is an emergent treatment schedule in which low doses of cytotoxic agents are given orally continuously, with no or short drug-free intervals. In general, it provides better tolerance, especially in patients who have been previously exposed to other oncologic treatments, with a favorable cost-effectiveness profile. It is well known that all these low-dos...

Journal: :Biomaterials 2013
De-Hong Yu Fu-Qiang Ban Mei Zhao Qin Lu Jonathan F Lovell Fan Bai Chao Wang Ying-Yun Guan Xin Luan Ya-Rong Liu Chao Fang Hong-Zhuan Chen

Metronomic chemotherapy aiming at inhibiting tumor angiogenesis with conventional chemotherapeutics is a promising strategy for antiangiogenic cancer therapy. However, current metronomic chemotherapy mainly focuses on free small-molecule drugs, without any effort to achieve tumor-specific biodistribution, which may lead to long-term toxicity concerns. Metronomic chemotherapy using nanoparticula...

Journal: :Cancer research 2007
Aparna A Kamat Tae Jin Kim Charles N Landen Chunhua Lu Liz Y Han Yvonne G Lin William M Merritt Premal H Thaker David M Gershenson Farideh Z Bischoff John V Heymach Robert B Jaffe Robert L Coleman Anil K Sood

Metronomic chemotherapy is the frequent administration of low doses of chemotherapeutic agents targeting tumor-associated endothelial cells. We examined the efficacy of metronomic taxanes alone and in combination with AEE788-a dual epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) inhibitor-in an orthotopic mouse model of ovarian cancer. Growth-modu...

Journal: :Tumori 2011
Elena Collovà Federica Sebastiani Elisabetta De Matteis Daniele Generali Gaetano Aurilio Francesco Boccardo Sergio Crispino Giorgio Cruciani

AIMS AND BACKGROUND Metronomic chemotherapy refers to the administration of low doses of cytotoxic agents over a prolonged period of time with no or only short drug-free intervals. It is designed to overcome acquired tumor resistance to chemotherapy and reduce neo-angiogenesis despite a lower toxicity than with standard chemotherapy. The role of metronomic chemotherapy remains controversial, an...

Journal: :Oncology reports 2015
Fei Yuan Hailong Shi Jun Ji Qu Cai Xuehua Chen Yingyan Yu Bingya Liu Zhenggang Zhu Jun Zhang

To evaluate the inhibitory effect and mechanism of capecitabine metronomic chemotherapy on gastric cancer cells. In vitro, the effects of 5-fluorouracil (Fu) metronomic chemotherapy on proliferation, apoptosis, tube formation ability, and angiogenesis were detected. In vivo, Ki-67, CD34 and VEGF were detected by immunohistochemical staining (IHC). Flow cytometry was used to detect the percentag...

Journal: :Haematologica 2013
Eleftheria Hatzimichael Evangelos Briasoulis

2017
Malgorzata Banys-Paluchowski Eugen Ruckhäberle Florian Schütz Natalia Krawczyk Tanja Fehm

Conventional chemotherapy is based on the “maximum tolerated dose” principle and aims at administering high doses of cytotoxic drugs followed by a rest period necessary for the body to recover. In the last decades alternative strategies have been developed to avoid serious side effects of conventional treatment, among them the metronomic chemotherapy. Much like a metronome keeps steady rhythm, ...

Journal: :Journal of Pharmacology and Pharmacotherapeutics 2014

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Sylvia S W Ng Alex Sparreboom Yuval Shaked Christina Lee Shan Man Neil Desai Patrick Soon-Shiong William D Figg Robert S Kerbel

PURPOSE Low-dose metronomic chemotherapy treatments, especially when combined with 'dedicated' antiangiogenic agents, can induce significant antitumor activity without serious toxicity in various preclinical models. It remains unclear, however, whether some cytotoxic drugs are better suited for metronomic regimens than others. Paclitaxel appears to be a strong candidate for metronomic chemother...

2016
Bergthor Björnsson Maria Albertsson Per Sandström

Background Metastatic Cholangiocarcinoma is a disease with a dismal prognosis. Treatment options are few, survival short and the side effects of treatments are burdensome. Metronomic chemotherapy can offer tumour regression and palliation. In this study we explore the responses of three patients to this treatment method in cases where conventional chemotherapy treatment has failed. Methods Thre...

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