This study was conducted to determine effects of methyltestosterone on innate immunity and adaptive immunity against Salmonella Pullorum in dwarf chicks. In vivo experiment, comparisons of pathological sections, viable counts of bacteria, specific antibody levels, and subsets of T lymphocytes were set forth between chicks with or without 10(-7) M methyltestosterone treatment (2 d of age through...

Methyltestosterone (17ar-methyl-17/3-hydroxyandrost-4-ene-3one) is an androgen which is orally effective and has had wide clinical use. We have treated patients with methyltestosterone for their advanced breast cancer (1). The compound led to a substantial decrease in urinary gonad-stimulating hormone similar to that seen after the parenteral administration of testosterone propionate. However, ...

After the daily administration of methyltestosterone to normal human subjects for several weeks, creatine usually appears in the urine in gradually increasing amounts (1,2). Because the creatinuria so induced is associated with an increase in the concentration of serum creatine, and also because the amount of urinary creatinine increases, it has been generally assumed that the synthesis of crea...

Metabolism of steroid hormones with anabolic properties was studied in vitro using human recombinant CYP3A4, CYP2C9 and 2B6 enzymes. The enzyme formats used for CYP3A4 and CYP2C9 were insect cell microsomes expressing human CYP enzymes and purified recombinant human CYP enzymes in a reconstituted system. CYP3A4 enzyme formats incubated with anabolic steroids, testosterone, 17alpha-methyltestost...

OBJECTIVES To investigate the cognitive effects of high-dose oral estrogen alone or in combination with oral methyltestosterone in postmenopausal women. METHODS Participants were tested with a randomized, double-blind design on the Identical Pictures, Cube Comparisons, Building Memory and Shape Memory tasks before and after 4 months of hormone treatment. RESULTS Women receiving estrogen and...

the objective of this study was to determine the efficacy of two procedures i.e. feeding and immersion followed by feeding, for masculinizing blue hap. two experiments (experiments i and ii) were conducted. in experiment i, feeding hormonal treatment was applied on post-yolk sac stage fry (10 days after fertilization at 27ºc). dosages of 30mg (group a) and 60mg (group b) of 17α-methyltestostero...

In the present study, the efficacy of letrozole, a potent nonsteroidal aromatase inhibitor, and 17α-methyltestosterone on gondal sex differentiation and sex reversal was examined in Mozambique tilapia (Oreochromis mossambicus). Among the doses tried in the experiment, 100 mg letrozole, 200 mg letrozole, and 50 mg 17α-methyltestosterone/kg produced male dominated populations (97-100% males). The...