The cancer potency of methylhydrazine by the inhalation route was estimated from dose-response data for multiple methylhydrazine-responsive tumor sites among female mice exposed by inhalation (Kinkead et al., 1985). These sites were nasal and respiratory mucosa, lung, liver, and blood vessels. For each of these tumor sites, a probability distribution of cancer potency estimates was derived usin...

reasonable to suppose that the ratio k(Gly. Gly)/ kl(Leu. Gly) gives an approximate estimate of the relative selectivities of the reagents towards the splitting of peptide bonds. A simple calculation from the results in Table 2 gives a value of the ratio of 5 for aqueous hydrochloric acid and average values of 16 for methylhydrazine and 22 for hydrazine. Therefore the selectivity of the reagent...

The electrooxidation of methylhydrazine, 1,2-dirnethylhydrazine, and 1,1 -dimethylhydrazine at a platinum electrode was studied using chronopotentiometry, coulometry, and product analysis. The results show that methjJlhydrazine is oxidized in an over-all four-electron reaction to nitrogen and methanol. The oxidation of 1,2-dimethylhydvazine proceeds by an initial two-electron oxidation, followe...

Gyromitrin, acetaldehyde N-methyl-N-formylhydrazone, is a toxin present in edible wild mushroom Gyromitra esculenta. At 37 degrees under different acidic conditions (pH 1 to 3), mimicking the milieu of human stomach, gyromitrin is converted to methylhydrazine, a known tumor inducer in mice and hamsters, through an intermediate, N-methyl-N-formylhydrazine. In addition, methylhydrazine is formed ...

We herein present the first in-depth theoretical study devoted to elucidate the mechanism of the reaction between 1,2,4-oxadiazole derivatives and methylhydrazine. For this purpose, the reaction between methylhydrazine and some polyfluoroaryl-1,2,4-oxadiazoles has been employed as a model reaction. The analysis of the potential energy surface (PES) indicates that the most favorable path involve...

In the present paper, we report an expedient total synthesis of triciribine, a tricyclic 7-deazapurine nucleoside and protein kinase B (AKT ) inhibitor, in 35% overall yield. Our synthesis route features a highly regioselective substitution of 1-N-Boc-2-methylhydrazine and a trifluoroacetic acid catalyzed one-pot transformation which combined the deprotection of the tert-butylcarbonyl (Boc) gro...

A 0.01% solution of methylhydrazine was administered daily in the drinking water of 6-week-old randomly bred Syrian golden hamsters for the remainder of their lifetime. The treatment gave rise to malignant histiocytomas of liver and tumors of the cecum. Thirty-two % of the females and 54% of the males developed malignant histiocytomas whereas among the controls no such lesions were seen. The in...