Iridium-catalyzed selective α-dimethylation and α-methylation of ketones or phenylacetonitriles, using methanol as the methylating agent, were achieved. In addition, three-component cross α-methyl-alkylation was successfully performed using methyl ketones with methanol and primary alcohols with long-chain alkyl groups. This method provides a very convenient direct route to α-methylated ketones,...

A highly enantioselective direct Mannich reaction of methyl alkyl ketones with cyclic imines benzo[e][1,2,3]oxathiazine 2,2-dioxides, catalyzed by the combination of cinchona alkaloid derived primary amine and TFA, is disclosed. For unsymmetrical methyl alkyl ketones, it is favoured that specific regioselective addition to the imine substrates occurs at the less-substituted methyl group by ster...

Although the oxidation of fatty acids by molds has received only superficial study, it has been found that Penicillium roqueforti forms methyl ketones as products of the oxidation. The distinctive taste and odor of bleu cheese is suggestive of 2-heptanone (Hammer and Bryant, 1937), and this compound, together with other methyl ketones, has been isolated from a ripe cheese and identified (Patton...

The sustainable byproduct catalyzed domino strategy has been performed for the facile synthesis of α-formyloxy and acetoxy ketones via iodination/nucleophilic substitution/hydrolyzation/oxidation sequences from simple and readily available aromatic ketones/unsaturated methyl ketones.

1. The hypoglycaemic and hypoketonaemic effects of orally administered methyl palmoxirate were studied in streptozotocin/alloxan-induced diabetic dogs. 2. Single oral 50 mg doses (approximately 7.5 mg kg-1) of methyl palmoxirate produced statistically significant reductions of plasma glucose (32 +/- 6% maximum reduction from baseline) and ketones (74 +/- 12% maximum reduction from baseline), wi...

We present a mild way of converting secondary methyl ethers into ketones using calcium hypochlorite in aqueous acetonitrile with acetic acid as activator. The reaction is compatible with various oxygen- and nitrogen-containing functional groups and afforded the corresponding ketones in up to 98% yield. The use of this methodology could expand the application of the methyl group as a useful prot...

1. The (14)C-labelling of the fatty acids and the methyl ketones in steam-distillates of milk fat from a lactating cow that had been injected intravenously with [1-(14)C]acetate was determined. 2. The labelling patterns of the C(6)-C(16) fatty acids and the corresponding methyl ketones with one fewer carbon atoms were similar, particularly so for the C(5)-C(10) compounds at 9 and 22hr. after th...

reaction of readily available 2-formyl -1-methyl-5-nitroimidazole (1) with 4-substituted-2-hydrazinothiazoles (2) afforded 2-formyl-l-methyl-5- nitroimidazole 4-substituted -2- thiazolylhydrazones (3). reaction of thiochromitn-4-one (4) with thiosemicarbazide gave thiochroman-4- one thiosemicarbazone (5). reaction of compound 5 with clc- haloaldehyde or ketones y ielded thiochroman--#-one 4-sub...