نتایج جستجو برای: methimazole

تعداد نتایج: 960  

Journal: :iranian journal of pharmaceutical research 0
fahimeh jalali department of chemistry-razi university zahra hatami department of chemistry razi university

a fast and simple voltammetric method for the determination of methimazole in pharmaceutical products was reported. a glassy carbon electrode was pretreated by anodization at +1.75 v (vs. sce) for 5 min, followed by potential cycling in the range of 0.3-1.3 v (20 cycles). the pretreated electrode showed an excellent electrocatalytic effect on the oxidation of methimazole. compared with untreate...

Journal: :galen medical journal 0
farshid gheisari assistant professor of nuclear medicine – shiraz university of medical sciences, shiraz, iran gholamreza pishdad professor of endocrinology – shiraz university of medical sciences, shiraz, iran mehrdad emami department of neurology – shiraz university of medical sciences, shiraz, iran kasra behdad department of neurology – shiraz university of medical sciences, shiraz, iran aida karimpour department of neurology – shiraz university of medical sciences, shiraz, iran maryam sharifian department of neurology – shiraz university of medical sciences, shiraz, iran

introduction: the aim of this study was to investigate the effect of methimazole on technetium-99m reabsorbing by thyroid gland , it may be possible to perform thyroid scan when the patients are on the methimazole, this can be time saving and decrease the adverse effects of discontinuing methimazole. patients and methods: among all the patients with hyperthyroidism who referred to nuclear medic...

2017
Hongjian Ji Feng Yue Jianxiang Song Xiaohua Zhou

BACKGROUND Methimazole is an antithyroid drug that is widely used for the treatment of hyperthyroidism. As an inhibitor of the enzyme thyroperoxidase, methimazole is generally well-tolerated. However, there have been increasing reports of methimazole-induced liver damage, although this effect of methimazole has been limited by the absence of objective diagnosis of the liver condition or the ina...

Journal: :Drug and chemical toxicology 2013
Reza Heidari Hossein Babaei Mohammad Eghbal

Methimazole is an antithyroid drug widely used in the treatment of hyperthyroidism. Administration of this drug, often in a chronic manner, is associated with several adverse drug reactions in humans, including life-threatening hepatotoxicity. This study attempted to investigate the cytotoxic mechanism(s) of methimazole toward isolated rat hepatocytes. In addition, the role of proposed methimaz...

Journal: :International journal of clinical and experimental medicine 2015
Hua Yang Xiaojuan Bi Hong Tang Juanhua Zeng Yilei Cong Tengfei Wu Qiuye Chen

OBJECTIVE To observe the clinical efficacy and safety of the traditional Chinese medicine (TCM) mixture Yingliu combined with methimazole medication for the treatment of Graves disease (GD). METHOD In a randomized, paralleled control study, 92 GD patients were randomized into a Yingliu mixture treatment and a control treatment group, both receiving methimazole. Both treatments lasted for 12 w...

Journal: :Advanced pharmaceutical bulletin 2014
Reza Heidari Hossein Babaei Leila Roshangar Mohammad Ali Eghbal

PURPOSE Methimazole is the most convenient drug used in the management of hyperthyroid patients. However, associated with its clinical use is hepatotoxicity as a life threatening adverse effect. The exact mechanism of methimazole-induced hepatotoxicity is still far from clear and no protective agent has been developed for this toxicity. METHODS This study attempts to evaluate the hepatotoxici...

Journal: :Scientia pharmaceutica 2015
Reza Heidari Akram Jamshidzadeh Nahid Keshavarz Negar Azarpira

Methimazole is the most widely prescribed antithyroid medication in humans. However, hepatotoxicity is a deleterious adverse effect associated with methimazole administration. No specific protective agent has been developed against this complication yet. This study was designed to investigate the role of taurine as a hepatoprotective agent against methimazole-induced liver injury in mice. Diffe...

Journal: :Dalton transactions 2015
Francesco Isaia Maria Carla Aragoni Massimiliano Arca Alexandre Bettoschi Claudia Caltagirone Carlo Castellano Francesco Demartin Vito Lippolis Tiziana Pivetta Elisa Valletta

The tetrahedral S-coordinated complex [Zn(MeImHS)4](ClO4)2, synthesised from the reaction of [Zn(ClO4)2] with methimazole (1-methyl-3H-imidazole-2-thione, MeImHS), reacts with triethylamine to yield the homoleptic complex [Zn(MeImS)2] (MeImS = anion methimazole). ESI-MS and MAS (13)C-NMR experiments supported MeImS acting as a (N,S)-chelating ligand. The DFT-optimised structure of [Zn(MeImS)2] ...

2016
Fahimeh Jalali Zahra Hatami

A fast and simple voltammetric method for the determination of methimazole in pharmaceutical products was reported. A glassy carbon electrode was pretreated by anodization at +1.75 V (vs. SCE) for 5 min, followed by potential cycling in the range of 0.3-1.3 V (20 cycles). The pretreated electrode showed an excellent electrocatalytic effect on the oxidation of methimazole. Compared with untreate...

Journal: :Advanced pharmaceutical bulletin 2013
Reza Heidari Hossein Babaei Mohammad Ali Eghbal

PURPOSE Methimazole is a drug widely used in hyperthyroidism. However, life threatening hepatotoxicity has been associated with its clinical use. No protective agent has been found to be effective against methimazole induced hepatotoxicity yet. Hence, the capacity of organosulfur compounds to protect rat hepatocytes against cytotoxic effects of methimazole and its proposed toxic metabolite, N-m...

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