Background: To study methaemoglobin content and NADH-methaemoglobin reductase activity of three human erythrocyte genotypes (HbAA, HbAS and HbSS).Materials and Methods: Studies to ascertain methaemoglobin concentration and level of NADH-methaemoglobin reductase activity of three human erythrocyte genotypes (HbAA, HbAS and HbSS) were carried out in forty-three (43) healthy male participants of c...

background: to study methaemoglobin content and nadh-methaemoglobin reductase activity of three human erythrocyte genotypes (hbaa, hbas and hbss).materials and methods: studies to ascertain methaemoglobin concentration and level of nadh-methaemoglobin reductase activity of three human erythrocyte genotypes (hbaa, hbas and hbss) were carried out in forty-three (43) healthy male participants of c...

In idiopathic methaemoglobinaemia, of which we have investigated'some cases, the occurrence of an atypical form of methaemoglobin' abnormally resistant to reduction has been postulated by Lian, Frumusan & Sassier [1939] as an aetiological factor. It thus became of interest to examine the evidence which has been put forward by Vestling [1942] against the unitary view of methaemoglobin. This auth...

The changes in intermediate haemoglobins produced during methaemoglobin reduction by NADPH-flavin reductase were analysed by an isoelectric-focusing method. The alpha 3+ beta 2+ and alpha 2+ beta 3+ valency hybrids were observed as intermediate haemoglobins and changed consecutively with time during the reaction. On the basis of the analyses, the course of methaemoglobin reduction was found to ...

Introduction Subdural haematoma (SDH) is a form of traumatic brain injury that can be classified as acute, subacute or chronic, based upon time from injury. When acute, it is a medical emergency in which surgical decompression is the only option to prevent mortality. Small subdurals and those that are no longer actively bleeding may be left to re-absorb spontaneously and clinical decision-makin...

The time course of methaemoglobin reduction in human erythrocytes treated with nitrite was studied at pH 7.4, 37 degrees C, in the presence or absence of Methylene Blue, and the changes in methaemoglobin, intermediate haemoglobins and oxyhaemoglobin during the reaction were analysed by isoelectric-focusing on Ampholine/polyacrylamide-gel plates. In both cases, with or without the dye, the inter...

We report the first case of methaemoglobinaemia induced by mesalazine. A woman suffering diarrhea and abdominal pain was initially treated with sulfamethoxazole–trimethoprim (TMP–SMX) and metronidazole for suspected infectious colitis. The treatment was stopped after ten days and she was referred to a gastroenterologist. A colonoscopy showed features resembling inflammatory bowel disease. Histo...

In view of the fact that aniline is absorbed not only by inhalation but also through the skin, the aerial contamination alone is not an exact indication of exposure. It is necessary to find a biological test which reveals exposure and is independent of the route of absorption. It is conceivable that the p-aminophenol excretion in the urine, which is a well-known symptom of aniline intoxication,...