Methadone overdoses are increasing in parallel with the increased frequency of opiate substitution therapy in adults. Although unintentional methadone intoxication in children is rare, it is becoming more frequently recognized. We report 3 cases of unintentional methadone overdose in toddlers who initially displayed central nervous system depression associated with severe nonketotic hyperglycem...

how to cite this article: fayyazi a, khajeh a, bagheri m, ahmadi s. acute hydrocephaly following methadone intoxication in a child. iranian journal of childneurology 2012;6(1):35-38. infantile methadone intoxication has been on the rise since the usage of methadone in opioid detoxification programs. we report a 30-month-old child with encephalopathy and acute hydrocephaly following methadone in...

background: acute opioid overdose is a common cause of admission in emergency department. in spite of the fact that naloxone is the main therapy for decades, there are controversies about the proper way of its use. this study aimed to compare two most recommended administration modes for naloxone. methods: in this single-blind clinical trial, 80 patients with methadone overdose syndrome were ra...

Methadone is used in the treatment of opioid addiction. Acute intoxication can lead to severe consequences and can even be lethal. In several case reports and small series, a presumably toxic leukoencephalopathy is described resulting from inhalation of heroin. We present the case of a 3-year-old boy who ingested methadone accidentally. In a coma with acute obstructive hydrocephalus owing to ma...

A 29-year-old man presented with comatose after methadone intoxication. Cerebral tomography only showed cortico-subcortical hypodense signal in the right cerebellar hemisphere. Brain MRI showed a rare imaging of FLAIR and DWI hyperintensities in the two cerebellar hemispheres as well as basal ganglia (globi pallidi), compatible with methadone overdose. To our knowledge this is the first reporte...

Background: Methadone is a synthetic opioid that has been used to relieve severe pain in addiction withdrawal. Unfortunately, due to non-standard supply and storage, the incidence of poisoning and deaths caused by this drug is increasing daily. The purpose of this study was to determine the underlying causes of methadone poisoning in children admitted to Kerman Afzalipour Hospital, Kerman Unive...

we reports a six-year-old child with autistic disorder and methadone intoxication. developmental disorders may mislead the caretakers and doctors to interpret the clinical manifestation and behavioral changes of these patients. methadone indigestion can be fatal in children even in a tiny amount and cardiac monitoring should be performed at least for the first 24 hours. the pervasive prescripti...

BACKGROUND Methadone maintenance treatment is the most widely prescribed treatment for opiate dependence with proven benefits for patients. In naïve users or in case of recreational misuse, methadone can be a source of potentially lethal intoxications, resulting in fatal overdoses. A few cases of infantile intoxications have been described in the literature, some of which resulted in death. Now...

how to cite this article: bazmamoun h, fayyazi a, khajeh a, sabzehei mk, khezrian f. a study of methadone-poisoned children referred to hamadan’s be’sat hospital iran. iran j child neurol. 2014 spring 8(2):34-37. objective increasing use of methadone in withdrawal programs has increased methadone poisoning in children. this research aimed to study the causes of incidence of poisoning in childre...