in asthmatic subjects there is a pronounced diurnal variation in bronchial responsiveness. if this phenomenon is due to variation in factors that control drug delivery, then it should be paralleled by a similar variation in competitive antagonist blockade. in order to study this possibility, we performed the methacholine challenge test and after 45 minutes, administered atropine by inhalation. ...

Background Airway hyperresponsiveness (AHR) is a feature of asthma in which airways are hyperreactive to stimuli causing extensive airway narrowing. Methacholine provocations assess AHR patients mainly by direct stimulation smooth muscle cells. Using vivo mouse models, mast cells have been implicated AHR, but the mechanism behind has remained unknown. Methods Cpa3Cre/+mice, lack cells, were use...

In asthmatic subjects there is a pronounced diurnal variation in bronchial responsiveness. If this phenomenon is due to variation in factors that control drug delivery, then it should be paralleled by a similar variation in competitive antagonist blockade. In order to study this possibility, we performed the methacholine challenge test and after 45 minutes, administered atropine by inhalat...

chronic cough is a common problem in patients visiting physicians and its prevalence in different populations range from 3 to 40%. postnasal drip, asthma and gastroesophageal reflux are the known cause of chronic cough. although diagnosis of asthma is usually made by clinical signs and spirometeric results, methacholine challenge test is a good diagnostic test in patients who show normal physic...

3-hydroxy-3-methylglutaryl-coa reductase inhibitors (statins), are effective serum cholesterol-lowering agents which also have anti-inflammatory properties. the objective of this study was to evaluate the effect of atorvastatin on bronchial hyperresponsiveness. adult patients (age 14 to 65 years) with bronchial hyperresponsiveness (bhr) diagnosis based on the spirometry with methacholine challe...

conclusions these results showed the preventive effect of hydroethanolic extract of n. sativa on tracheal responsiveness of guinea pig model of copd, which was as effective as vitamin c. results the tracheal responsiveness to both methacholine and ovalbumin in guinea pigs with copd were significantly higher than those of controls (p < 0.001 for both cases). the tracheal responsiveness in the co...

Objective: Asafoetida (Ferula assa-foetida) is known as a valuable remedy for whooping cough, pneumonia, bronchitis in children and asthma treatment in folk medicine. In the present study the relaxant effects of the asafoetida on tracheal smooth muscle of guinea pigs and its probable mechanism(s) were examined. Materials and Methods: The relaxant effects of three cumulative concentrations of t...