objective(s): this study evaluated the effect of swimming exercise during spontaneous methamphetamine (meth) withdrawal on the anxiety, depression, obsessive-compulsive disorder (ocd) and voluntary meth consumption in meth-dependent rats.  materials and methods: male wistar rats were repeatedly administered with bi-daily doses of meth (2 mg/kg, subcutaneous) over a period of 14 days. exercised ...

background: iran is facing an outbreak of methamphetamine-induced disorders and frequent use of these substances in patients with bipolar disorder. using or intoxication of methamphetamine in patients with bipolar i disorder may alter the patient's clinical profile; however there is limited studies about impact of methamphetamine on clinical manifestation of bipolar disorders. this study aimed ...

Objective(s): This study evaluated the effect of swimming exercise during spontaneous methamphetamine (METH) withdrawal on the anxiety, depression, obsessive-compulsive disorder (OCD) and voluntary METH consumption in METH-dependent rats.  Materials and Methods: Male Wistar rats were repeatedly administered with bi-daily doses of METH (2 mg/kg, subcutaneous) over a period of 14 days. Exercised ...

objective: the anxiety profile in the stimulant-sensitized animals is not clear. thus, this study was conducted to elucidate the effects of acute and chronic administration of methamphetamine (meth) on the anxiety profile. the aim of this study was to examine whether meth-sensitized rats would show an increase in the expression of anxiogenic-like behaviors and to determine whether a low dose of...

Methamphetamine (METH) is a synthetic drug with severe neurotoxicity, however, the regulation of METH-induced neuronal programmed necrosis remains poorly understood. The aim this study was to identify molecular mechanisms necrosis. We found that occurred in striatum brain samples from human and mice were exposed METH. receptor-interacting protein kinase 3 (RIP3) highly expressed neurons METH, R...

Methamphetamine (METH) abuse causes neurodegeneration. Medicinal herb such as crocin has neuroprotective properties. The current study evaluates the role of CREB-BDNF signaling pathway in mediating the neuroprotective effects of crocin against METH-induced neurodegeneration in rats. Sixty adult male rats were divided randomly into group 1 and group 2 which received 0.7 mL/rat ...

Methamphetamine (meth) is a neurotoxic psychostimulant that increases monoamine oxidase (MAO)-dependent mitochondrial oxidant stress in axonal but not somatic compartments of substantia nigra pars compacta (SNc) and locus coeruleus (LC) neurons. Chronic meth administration results the degeneration SNc LC neurons male mice, MAO inhibition neuroprotective, suggesting deleterious effects chronic b...

objective(s): there is controversial evidence about the effect of methamphetamine (meth) on spatial memory. we tested the time- dependent effects of meth on spatial short-term (working) and long-term (reference) memory in meth –sensitized and withdrawn rats in the morris water maze. materials and methods: rats were sensitized to meth (2 mg/kg, daily/5 days, sc). rats were trained in water maze ...