intraocular metastatic tumors have been increasingly reported in the recent past. unlike choroidal metastasis, metastasis to retina is very rare and so far has been reported in very few case reports only. case presentation : a 56 year-old male who presented with a history of adenocarcinoma of the cecum and underwent lap colectomy for the primary cecal tumor, received adjuvant chemotherapy for a...

BACKGROUND/AIMS To report a case of cutaneous malignant melanoma with cerebral metastasis found to have vitreoretinal metastasis upon referral for neovascular glaucoma. METHODS The clinical history and ocular examination findings, including histologic, cytologic, genetic, and immunohistochemical features of the vitreoretinal metastatic tumor, were reviewed. Additionally, the histologic and im...

Abstract Angiopoietin-2 (ANGPT2) is a context-dependent TIE2 agonistic or antagonistic ligand that induces diverse responses in cancer. Blocking ANGPT2 provides promising strategy for inhibiting tumor growth and metastasis, yet variable effects of targeting have complicated drug development. ANGPT2443 naturally occurring, lower oligomeric protein isoform whose expression increased Here, we use ...

Purpose To report the swept-source optical coherence tomographic (OCT) findings in two eyes with choroidal metastases. Observations Two patients with choroidal metastasis were studied. The metastasis was from a breast cancer in Case 1 and from a lung cancer in Case 2. In Case 1, swept-source OCT showed a highly reflective solid tumor with low optical reflective tissues that had replaced the c...

Metastatic carcinoma is the most common intraocular malignancy in the adult population, and the most common primary cancers are breast cancer, followed by lung cancer [1]. In all ocular metastases, uveal metastasis is the most common form. The choroid is the most common site for uveal metastasis [2]. Shah et al. [3] investigated 194 patients with uveal metastasis from lung cancer and found that...

purpose: to report a uveal metastasis from infiltrative ductal carcinoma of breast. case report: a 45 year old woman with 9 year history of left breast ductal carcinoma and axillary lymph nodes involvement has found soft tissue are right eye uveal metastasis after 5 and 9 years respectively. conclusion: every patient with breast carcinoma should have complete eye examination at least every 6 mo...

Introduction: Lead toxicity induces retinal cell apoptosis. Vitamin C and garlic may decrease lead-induced apoptosis. This study was undertaken to investigate vitamin C and garlic protective effects on lead-induced apoptosis in eye retina. Methods: Pregnant Wistar rats (n = 72) were divided randomly into 9 groups: (L) treated rats with lead acetate in drinking water and (L+AA) with leaded water...