the identification of multipotential mesenchymal stem cells (mscs) derived from adult human tissues such as bone marrow and connective tissues has provided exciting prospects for cell-based tissue engineering and regeneration. this review article focuses on the biology of mscs, their differentiation potentials in vitro and in vivo, and their application in tissue engineering. our current unders...

helicobacter pylori was the main cause of gastric cancer (gc) in all over the world that results in intestinal- and diffuse-type carcinoma. infection by this bacterium remains chronic for a long time. in vitro studies have highlighted the role of stem cells in gc. h. pylori infection results in tissue injury and the adult/tissue stem cells subsequently start to replace the dead cells. the genet...

tissue engineering based on the adipose derived stem cells  promote a strong strategy to propagation of bone, cartilage and fat tissues in the three-dimensional scaffolds, fabricated by combining biological materials with suitable and appropriate growth factors.  in this study, a peo scaffold was used to show that mesenchymal stem cells can attach well; the aim of this study was the investigati...

Spinal cord injury (SCI) is a neurologic disorder that have a significant impact on quality of life, life expectancy, and economic burden. SCI leads to irreversible neuronal loss and ultimately leads to paralysis. Mesenchymal stem cells (MSCs) are a promising source for cellular therapy because they have possessed the capacity of self-renewal and differentiation to several distinct mesenchymal ...

Background and Objective: Mesenchymal stem cells (MSCs) promote metastasis in colorectal cancer; however, the mechanism underlying this process is not fully understood. Epithelial to mesenchymal transition (EMT) is a key step in tumor acquisition of metastatic phenotype. We aimed to investigate the effect of MSCs on the expression of EMT markers, as well as cancer stem cell markers in HT-29 col...

conclusions although the aforementioned challenges must still be addressed, the potential of wjmscs in skin regenerative clinical treatments is promising. results similar to bone marrow mscs, wjmscs express major histocompatibility complex (mhc) class i molecules. evidence acquisition according to research conducted by various researchers, wharton’s jelly mesenchymal stem cells (wjmscs) have se...

mesenchymal stem cells (mscs) could differentiate into various types of tissues. these cells serve as a backup for the regeneration and repair of tissues or cells after injury. a skin wound is defined as an injury to the skin that needs to be restored. all types of cells in skin especially mesenchymal stem cells play important role in wound healing process. in particular, paracrine signaling of...

Background: One of the key questions in biochemistry is why cell becomes aged and what are the involved factors? Why cell growth is stopped after some divisions and cells become senescent? This occurs in a greater frame in the whole body and cells dye after a while. Androgenetic alopecia (AGA) is characterized by a loss or decrease in hair follicle size, which could be related to the loss of ha...