background: primary focal segmental glomerulosclerosis (fsgs) is defined by the presence of proteinuria, often in nephrotic range and pathologically by segmental scars (ss). the aim of this study is to identify the possible predictors of complete remission or progression to chronic kidney disease in iranian adults with primary focal segmental glomerulosclerosis. methods: in this historical coho...

BACKGROUND Primary focal segmental glomerulosclerosis (FSGS) is defined by the presence of proteinuria, often in nephrotic range and pathologically by segmental scars (SS). The aim of this study is to identify the possible predictors of complete remission or progression to chronic kidney disease in Iranian adults with primary focal segmental glomerulosclerosis. METHODS In this historical coho...

The currently used classification reflects our understanding of the pathogenesis of the various forms of lupus nephritis, but clinicopathologic studies have revealed the need for improved categorization and terminology. Based on the 1982 classification published under the auspices of the World Health Organization (WHO) and subsequent clinicopathologic data, we propose that class I and II be use...

The Oxford classification for the pathological classification of a glomerular disease in IgA nephropathy was established and published in 2009. Four of the pathological variables: 1) mesangial hypercellularity score, 2) segmental glomerulosclerosis, 3) endocapillary hypercellularity and 4) tubular atrophy/interstital fibrosis were presented as having value in predicting renal outcome in this gl...

Increases in mesangial cell number may herald glomerular scarring, but they are not irreversible. This study sought mechanisms by which surplus glomerular mesangial cells can be cleared. A small proportion of cultured mesangial cells exhibited typical morphological features of apoptosis (programmed cell death), which was increased by growth factor deprivation or exposure to cycloheximide, stimu...

Correspondence: Silvina Gutiérrez Centro de Microscopía Electrónica. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina. [email protected] [email protected] The classification of lupus nephritis was revised by the ISN/RPS in 2003. The increasingly recognized phenomenon of apparent minimal change disease (MCD) in the context of systemic lupus erythemato...

Heavy Chain Deposition Disease (HCDD) is rare, and presents with renal failure, proteinuria, hematuria, hypertension, and often hypocomplimenteniemia [1-3]. HCDD may mimic the pathology of immune complex, crescenteric glomerulonephritis, with isolated heavy chain deposits along mesangial, glomerular, and tubular Basement Membranes (BMs), without associated light chains [4]. The predominant heav...

BACKGROUND Several renal histopathological features, including mesangial hypercellularity, glomerulosclerosis, tubular atrophy and interstitial fibrosis, are considered to be independent predictors of end-stage renal failure in patients with glomerular diseases. Mesangial proliferative glomerulonephritis (MesPGN) is characterized by proliferations of mesangial cells with increase in mesangial m...