نتایج جستجو برای: menthofuran synthase

تعداد نتایج: 83626  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Soheil S Mahmoud Rodney B Croteau

(+)-Pulegone is a central intermediate in the biosynthesis of (-)-menthol, the most significant component of peppermint essential oil. Depending on environmental conditions, this branch point metabolite may be reduced to (-)-menthone en route to menthol, by pulegone reductase (PR), or oxidized to (+)-menthofuran, by menthofuran synthase (MFS). To elucidate regulation of pulegone metabolism, we ...

2011
Simon Atsbaha Zebelo Cinzia M. Bertea Simone Bossi Andrea Occhipinti Giorgio Gnavi Massimo E. Maffei

Interactions between herbivorous insects and plants storing terpenoids are poorly understood. This study describes the ability of Chrysolina herbacea to use volatiles emitted by undamaged Mentha aquatica plants as attractants and the plant's response to herbivory, which involves the production of deterrent molecules. Emitted plant volatiles were analyzed by GC-MS. The insect's response to plant...

Journal: :journal of medicinal plants and by-products 0

peppermint has considerable commercial value and widely cultivated for essential oil production, especially menthol. the aim of this study was to determine the quantitative expression of pulegone reductase (pr), menthofuran synthase (mfs) and limonene synthase (ls) genes in menthol biosynthesis pathway in mentha x piperita , using semiquantitative rt-pcr analysis and evaluating menthol producti...

2014
Birendra Kumar Himanshi Mali Ekta Gupta

Menthofuran rich eight half-sib seed progeny of Mentha piperita (MPS-36) were studied for various genetic parameters, namely, coefficient of variation, heritability, genetic advance, correlation, and path of various plant and oil attributes, namely, plant height, L:S ratio, herb yield, β -myrcene, limonene, 1,8-cineole, menthone, menthofuran, neomenthone, pulegone, and menthol. Maximum genotypi...

Peppermint has considerable commercial value and widely cultivated for essential oil production, especially menthol. The aim of this study was to determine the quantitative expression of pulegone reductase (pr), menthofuran synthase (mfs) and limonene synthase (ls) genes in menthol biosynthesis pathway in Mentha x piperita , using semiquantitative RT-PCR analysis and evaluating menthol producti...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2001
S S Mahmoud R B Croteau

Peppermint (Mentha x piperita L.) was independently transformed with a homologous sense version of the 1-deoxy-d-xylulose-5-phosphate reductoisomerase cDNA and with a homologous antisense version of the menthofuran synthase cDNA, both driven by the CaMV 35S promoter. Two groups of transgenic plants were regenerated in the reductoisomerase experiments, one of which remained normal in appearance ...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2003
L-J Chen E H Lebetkin L T Burka

(R)-(+)-Menthofuran is a metabolite of (R)-(+)-pulegone, the chief constituent of pennyroyal oil. Menthofuran has been shown to account for a significant percentage of pulegone toxicity through further metabolism to a reactive intermediate, an enonal (2-Z-(2'-keto-4'-methylcyclohexylidene)propanal). Hydration of the enonal followed by a 1,4-dehydration and rearrangement gives rise to diastereom...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Bernd Markus Lange Soheil Seyed Mahmoud Mark R Wildung Glenn W Turner Edward M Davis Iris Lange Raymond C Baker Rick A Boydston Rodney B Croteau

Peppermint (Mentha × piperita L.) was transformed with various gene constructs to evaluate the utility of metabolic engineering for improving essential oil yield and composition. Oil yield increases were achieved by overexpressing genes involved in the supply of precursors through the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway. Two-gene combinations to enhance both oil yield and compositi...

1998
SIAMAK C. KHOJASTEH-BAKHT LUKE L. KOENIGS RAIMUND M. PETER WILLIAM F. TRAGER SIDNEY D. NELSON

(R)-(1)-Menthofuran is a potent, mechanism-based inactivator of human liver cytochrome P450 (CYP or P450) 2A6. Menthofuran caused a timeand concentration-dependent loss of CYP2A6 activity. The inactivation of CYP2A6 was characterized by a Ki of 2.5 mM and a kinact of 0.22 min 21 for human liver microsomes and a Ki of 0.84 mM and a kinact of 0.25 min 21 for purified expressed CYP2A6. Addition of...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 1999
S C Khojasteh-Bakht W Chen L L Koenigs R M Peter S D Nelson

(R)-(+)-Pulegone, a monoterpene constituent of pennyroyal oil, is a hepatotoxin that has been used in folklore medicine as an abortifacient despite its potential lethal effects. Pulegone is metabolized by human liver cytochrome P-450s to menthofuran, a proximate hepatotoxic metabolite of pulegone. Expressed human liver cytochrome (CYP) P-450s (1A2, 2A6, 2C9, 2C19, 2D6, 2E1, and 3A4) were tested...

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