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Meningococcal disease remains a significant global public health and is unique among causes of bacterial meningitis and sepsis where it not only causes sporadic disease but also outbreaks. Meningococcal disease has a rapid onset with high mortality. The understanding of immunopathogenesis is crucial for development of novel therapeutic strategies and vaccines designed against meningococcal dise...

reports on the treatment of meningitis with penicillin, with sulphonamides, and with sulphouamides and anti-meningococcal serum. The following are some recent publications on the subject. Dawson and Hobby (1944) reported on the Use of penicillin in 100 cases out of which only 2 were of meningococcal meningitis. In one case the response was satisfactory; in the other Penicillin was not given int...

meningococcal disease remains a significant global public health and is unique among causes of bacterial meningitis and sepsis where it not only causes sporadic disease but also outbreaks. meningococcal disease has a rapid onset with high mortality. the understanding of immunopathogenesis is crucial for development of novel therapeutic strategies and vaccines designed against meningococcal dise...

Throughout the African meningitis belt, meningococcal meningitis outbreaks occur only during the dry season. Measles in Niger exhibits similar seasonality, where increased population density during the dry season probably escalates measles transmission. Because meningococcal meningitis and measles are both directly transmitted, we propose that host aggregation also impacts the transmission of m...

Meningococcal disease is a serious life-threatening bacterial infection caused by Neisseria meningitides with its most common clinical presentations: meningococcal meningitis (which has high morbidity and low mortality) and meningococcemia or Meningococcal septicemia (which has low morbidity and high mortality). Globally, Neisseria meningitidis causes meningitis in about 47.3% of cases and Meni...

In order to asses the clinical forms of meningococcal disease, we reviewed 201 cases diagnosed as meningococcal disease in the University Hospital of the Fluminense Federal University in Rio de Janeiro, 185 of which met the inclusion criteria. Clinical and laboratorial characterization allowed for grouping of the cases as follows: meningococcal meningitis, 18%; meningitis with septicemia, 62%; ...