bacillus calmette guerin (bcg) developed by albert calmette and camille guerin in france between 1908 and 1921 contained a live attenuated strain of mycobacterium bovis and was administered worldwide to prevent tuberculosis. bcg vaccination is also administered at birth to all the newborns in iran. disseminated bcg infection after bcg vaccination is rare. here in, we report 2 new cases of disse...

Abstract Background Mycobacteria include ubiquitous species of varying virulence. However, environmental and individual-specific factors, particularly host genetics, play a crucial role in the outcome exposure to mycobacteria. The first molecular evidence monogenic predisposition mycobacteria came from study Mendelian susceptibility mycobacterial disease (MSMD), rare inborn error IFN- γ immunit...

mendelian susceptibility to mycobacterial diseases (msmd) is a rare inheritance syndrome, characterized by a disseminated infection with mycobacterium in children following bcg vaccination at birth. regarding the vaccination program in iran, it may consider as a public health problem. the pathogenesis of msmd is dependent on either insufficient production of ifn-gamma (γ) or inadequate response...

Heterozygosity for dominant-negative STAT1 mutations underlies autosomal dominant Mendelian susceptibility to mycobacterial diseases. Mutations conferring Mendelian susceptibility to mycobacterial diseases have been identified in the regions of the STAT1 gene encoding the tail segment, DNA-binding domain and SH2 domain. We describe here a new heterozygous mutation, Y701C, in a Japanese two-gene...

A 13 year old female patient had multiple hospital visits since age of 6months. The most striking diagnosis was repeated mycobacterial infections; which were diagnosed at times clinically and other with bacteriological confirmation. She tuberculosis affecting lymph nodes, skin soft tissue, bone joints, lungs epidural para-spinal regions. has been treated 4 first line, ones second line anti-Tb d...