نتایج جستجو برای: mendelian

تعداد نتایج: 7468  

Journal: :Applied Mathematics & Information Sciences 2013

2013
Nasir Ganikhodjaev Mansoor Saburov Uygun Jamilov

In this paper, we attempt to provide mathematical models of Mendelian and Non-Mendelian inheritances of the bisexual population system having Fisher’s 1:1 principle. In our model, we always assume that distributions of the same phenotype of female and male populations are equal. We study the evolution of a Mendelian trait. As an application of a non-Mendelian inheritance, we construct a quadrat...

Journal: :American journal of human genetics 2015
Jessica X Chong Kati J Buckingham Shalini N Jhangiani Corinne Boehm Nara Sobreira Joshua D Smith Tanya M Harrell Margaret J McMillin Wojciech Wiszniewski Tomasz Gambin Zeynep H Coban Akdemir Kimberly Doheny Alan F Scott Dimitri Avramopoulos Aravinda Chakravarti Julie Hoover-Fong Debra Mathews P Dane Witmer Hua Ling Kurt Hetrick Lee Watkins Karynne E Patterson Frederic Reinier Elizabeth Blue Donna Muzny Martin Kircher Kaya Bilguvar Francesc López-Giráldez V Reid Sutton Holly K Tabor Suzanne M Leal Murat Gunel Shrikant Mane Richard A Gibbs Eric Boerwinkle Ada Hamosh Jay Shendure James R Lupski Richard P Lifton David Valle Deborah A Nickerson Michael J Bamshad

Discovering the genetic basis of a Mendelian phenotype establishes a causal link between genotype and phenotype, making possible carrier and population screening and direct diagnosis. Such discoveries also contribute to our knowledge of gene function, gene regulation, development, and biological mechanisms that can be used for developing new therapeutics. As of February 2015, 2,937 genes underl...

ژورنال: :genetics in the 3rd millennium 0
محمد حسن کریمی نژاد mohammad hassan kariminejad

بیماری های مندلی بیماری هایی هستند که ناشی از اثرات یک ژن بر فنوتیپ فرد می باشند. انتقال آنها از نسلی به نسل دیگر همانند الگوهایی است که مندل توضیح داد. اگر ژن بیماری ها بر روی کروموزوم های جسمی (اتوزوم) قرار داشته باشد این توارث را جسمی (autosomal) و اگر بر روی کروموزوم های جنسی قرار داشته باشد آن را توارث وابسته به جنس (sex-likned) می نامند. طرح توارث بیماری ها از طریق انتقال صفات در خانواده ...

Journal: :Cell 2013
David R. Blair Christopher S. Lyttle Jonathan M. Mortensen Charles F. Bearden Anders Boeck Jensen Hossein Khiabanian Rachel Melamed Raul Rabadan Elmer V. Bernstam Søren Brunak Lars Juhl Jensen Dan Nicolae Nigam H. Shah Robert L. Grossman Nancy J. Cox Kevin P. White Andrey Rzhetsky

Although countless highly penetrant variants have been associated with Mendelian disorders, the genetic etiologies underlying complex diseases remain largely unresolved. By mining the medical records of over 110 million patients, we examine the extent to which Mendelian variation contributes to complex disease risk. We detect thousands of associations between Mendelian and complex diseases, rev...

2017
Jack Bowden

1. Davey Smith G, Ebrahim S. ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003;32:1–22. 2. Burgess S, Timpson NJ, Ebrahim S, Davey Smith G. Mendelian randomization: where are we now and where are we going? Int J Epidemiol 2015;44:379–88. 3. Glymour MM, Tchetgen EJT, Robins JM. Credible Mendelian randomizat...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید