the aim of this study is to prepare novel sorbitol based extended release tablets by melt dispersion method using carbamazepine as a model drug. carbamazepine was melted along with sugar alcohol to get melt dispersion granules (mgds) and was characterized by differential scanning calorimetry (dsc), powder x-ray diffractometry (xrd) and solubility study. the physical and chemical parameters of m...

Melt dispersion experiments with lateral failure in the bottom head were carried out in a 1:18 scaled annular cavity design under low pressure conditions. Water and a bismut-alloy were used as melt simulant material and nitrogen as driving gas. With lateral breaches the liquid height in the lower head relative to the upper and lower edge of the breach is an additional parameter for the dispersi...

     The aim of this study is to prepare novel sorbitol based extended release tablets by melt dispersion method using carbamazepine as a model drug. Carbamazepine was melted along with sugar alcohol to get melt dispersion granules (MGDs) and was characterized by differential scanning calorimetry (DSC), powder X-ray diffractometry (XRD) and solubility study. The physical and chemical parameters...

Nanobiocomposites of poly(lactic acid) (PLA) with 3–5 wt% organically modified montmorillonite (OMMT) were prepared by melt compounding in two different mixers, miniature twin-screw extruder and internal batch mixer, leading to different degrees of dispersion. The progress of dispersion was characterized by melt rheology coupled with light attenuation. Processed PLA/OMMT samples showed percolat...

The effects of three different mixers, two different feeding orders and nanoclay content on the structure development and rheological properties of PE/nanoclay nanocomposite samples were investigated. Fractional Zener and Carreau–Yasuda models were applied to discuss the melt linear viscoelastic properties of the samples. Moreover, scaling law for fractal networks was used to quantify clay disp...

the human mdr1 gene encodes for a p-glycoprotein (pgp), which acts as an efflux pump that transports a large variety of substrates from the inside of cells to the outside until protection against xenobiotics. the g2677t/a polymorphism in exon 21 is associated with pgp expression and function in humans. the present study was aimed to determine the frequencies of this polymorphism in a healthy po...

Experiments were performed in a scaled annular cavity design, to investigate melt dispersal from the reactor pit when the reactor pressure vessel lower head fails at low system pressure of less than 2 MPa. In the part of the experimental program presented in this paper, the fluid dynamics of the dispersion process was studied using model fluids, water or bismuth alloy instead of corium, and nit...

Solid dispersion is molecular dispersion of drug in a polymer matrix which leads to improved solubility and hence better bioavailability. Solvent evaporation technique was employed to prepare films of different combinations of polymers, plasticizer, and a modal drug sulindac to narrow down on a few polymer-plasticizer-sulindac combinations. The sulindac-polymer-plasticizer combination that was ...

[1] Anelasticity and diffusion creep viscosity of partially molten rock analogue were measured experimentally at various melt fractions (0.0025–0.04). The presence of even a small quantity of melt phase causes a significant increase in attenuation and dispersion, and decrease in viscosity (melt effect). Similar changes are additionally caused by the presence of a secondary solid component (chem...

A new mechanism for fast reaction of Al nanoparticles covered by a thin oxide shell during fast heating is proposed and justified theoretically and experimentally. For nanoparticles, the melting of Al occurs before oxide fracture. The volume change due to melting induces pressures of 1–2 GPa and causes dynamic spallation of the shell. The unbalanced pressure between the Al core and the exposed ...