cerebral vasospasm considered to be a serious cause of morbidity and mortality following subarachnoid haemorrhage (sah).despite several available therapeutic options, current protocols do not prevent major consequences of vasospasm. inflammation is believed to play an important role in post-haemorrhagic vasospasm. meloxicam is a non-steroidal anti-inflammatory drug. the aim of this study was to...

the aim of the present investigation was to biotransform the anti-inflammatory compound meloxicam by enzymes present in whole cells of five actinomycete cultures to produce novel bioactive derivatives. among the actinomycetes screened, streptomyces griseus ncim 2622 was found to possess the enzyme system(s) that oxidize meloxicam into two metabolites whereas that present in s. griseus ncim 2623...

background: non-steroidal anti-inflammatory drugs (nsaid) have been associated with antioxidant property and have been shown to improve the circulating antioxidant status on daily dosing in different inflammatory conditions. the present study was conducted to investigate the antioxidant role of meloxicam in aluminum induced oxidative stress in rat brain. methods: in the in vivo experiments, spr...

Cerebral vasospasm considered to be a serious cause of morbidity and mortality following subarachnoid haemorrhage (SAH).Despite several available therapeutic options, current protocols do not prevent major consequences of vasospasm. Inflammation is believed to play an important role in post-haemorrhagic vasospasm. Meloxicam is a non-steroidal anti-inflammatory drug. The aim of this study was to...

To ascertain whether meloxicam used in a clinical setting as a non-steroidal anti-inflammatory drug (NSAID) warrants preclinical in vivo evaluation as an anticancer agent, we investigated its antitumor effects alone and in combination with radiation and/or 5-fluorouracil (5-FU) in cultured cells. Seven cell lines were examined for cyclooxygenase-2 (COX-2) protein expression by immunoblot analys...

Meloxicam is a new non-steroidal anti-inflammatory drug (NSAID) which preferentially inhibits cyclooxygenase-2 over cyclooxygenase-1. A double-blind parallel-group trial compared meloxicam 7.5 mg once daily (n = 199) with naproxen 750 mg (n = 180) in rheumatoid arthritis. There was no significant difference between the groups regarding the primary efficacy variables (global efficacy assessment ...

objective(s):drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. analgesics such as nsaids have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. meloxicam is one of nsaids with no topical form in the market. in this research, we attempted to quantify the skin permeation of a m...

Acetaminophen (Ace) and meloxicam (Mel) are the two types of analgesic and antipyretic medications. This study investigated the dose responses of acetaminophen and meloxicam on platelet aggregation and coagulation function in human blood samples. Blood samples were collected from six healthy humans and processed to make platelet-adjusted (100 × 10 cells/μl) blood samples. Acetaminophen (Tylenol...

Meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. The aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. Meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (PEG) 6000. The effect of solubilization by...

Anti-nociceptive efficacy of carprofen and meloxicam was evaluated in twelve female dogs brought for elective ovariohysterectomy randomly assigned to Group A and Group B. In Group A Carprofen was administered @ 4 mg/kg i.v, whereas in Group B, Meloxicam was administered @ 0.2 mg/ kg i.v, immediately after completion of surgery. Pain scores decreased significantly following analgesia with carpro...