introduction: hot flash affects approximately 75% of women with breast cancer. those who experience hot flashes have higher rates of sleep disorders, temper and lower quality of life than women with no hot flashes. the   persent   study   was aimed to compare the effect of megestrol acetate with gabapentin on the severity of hot flashes in patients with breast cancer materials and methods: in a...

PURPOSE Hepatocellular carcinoma (HCC) is generally considered as a sex hormone-dependent tumor, and hormonal therapy has been proposed as a strategy for the treatment of HCC. The aim of the study is to investigate the effect of megestrol acetate, a synthetic progesteronal agent, on growth of HepG2 cells in vitro and in vivo. EXPERIMENTAL DESIGN Cell growth in vitro was assessed by a colormet...

BACKGROUND Megestrol acetate is an effective treatment for improving appetite and increasing body weight in patients with cancer-associated anorexia. However, Megace oral suspension (OS), a micronized formulation of megestrol acetate, has low bioavailability in the fasting state. To overcome this limitation, a nanocrystal formulation has been developed. This study was performed to evaluate the ...

In the present study, solid dispersion nanoparticles with a hydrophilic polymer and surfactant were developed using the supercritical antisolvent (SAS) process to improve the dissolution and oral absorption of megestrol acetate. The physicochemical properties of the megestrol acetate solid dispersion nanoparticles were characterized using scanning electron microscopy, differential scanning calo...

OBJECTIVE To manage patients with dysfunctional uterine bleeding (DUB) according to endometrial thickness. METHODS A retrospective chart review of 49 patients who reported 8 or more days of bleeding was performed. They were then divided into three groups based on endometrial thickness (mm): less than 6, 6-11, and greater than 11. These three groups were treated with combined oral contraceptiv...

BACKGROUND Interleukin-15 (IL-15) and interleukin-18 (IL-18) are potential regulators of body composition in humans. The authors previously reported that megestrol acetate ingestion causes a large accumulation of adipose tissue and reduces muscle mass. Therefore, the purpose of this investigation was to evaluate the effects of megestrol acetate ingestion on circulating IL-15 and IL-18 concentra...

BACKGROUND Hot flashes are frequent in postmenopausal breast cancer patients, especially when treated with tamoxifen. Estrogen replacement therapy is the most effective treatment for hot flashes, but its use is controversial in breast cancer survivors. Progestins may offer a good alternative for the control of hot flashes in this setting; in particular, oral megestrol acetate has been proven ef...

Abb. 3. Schematischer Aufbau der Membranmatrix der peritrophischen Membran von Calliphora (Aufsicht), wie er sich ohne Berücksichtigung von Adsorption an der Oberfläche des Membranschlauches zur Zeit ergibt. A = vermutlich Mucopolysaccharidschicht (Glucose-14C-Einbau, 210Pb-Austausch), Querbanden ca. 30—40 /x, Längsbanden ca. 5 — 1— fi. B = vermutlich Proteinschicht (Acetat-14C-, Phosphat-32P-A...