Aortic medial amyloid (AMA) is the most common localized human amyloid, occurring in virtually all of the Caucasian population over the age of 50. The main protein component of AMA, medin, readily assembles into amyloid-like fibrils in vitro. Despite the prevalence of AMA, little is known about the self-assembly mechanism of medin or the molecular architecture of the fibrils. The amino acid seq...

Poliomyelitis (Heine-Medin disease) T he recent death of FC Robbins 1 , Nobel laureate and pioneer worker who cultivated the poliomyelitis virus, prompts this note. Poliomyelitis pre-dates recorded history. 2 Biblical descriptions of the lame and crippled lack sufficient detail for diagnosis. However, a funereal stele of the priest Ruma from the 19th Egyptian dynasty shows shortening and marked...

According to the diversity principle, diverse evidence is strong evidence. There has been considerable evidence that people respect this principle in inductive reasoning. However, exceptions may be particularly informative. Medin, Coley, Storms, and Hayes (2003) introduced a relevance theory of inductive reasoning and used this theory to predict exceptions, including the nondiversity-by-propert...

Thirty-one proteins are known to form extracellular fibrillar amyloid in humans. Molecular information about many of these proteins in their monomeric, intermediate or fibrillar form and how they aggregate and interact to form the insoluble fibrils is sparse. This is because amyloid proteins are notoriously difficult to study in their soluble forms, due to their inherent propensity to aggregate...

introduction: the aim of this study was to compare centering ability and dentin removal of three rotary systems in curved root canals of extracted teeth. materials and methods: sixty root canals of mandibular first molars with curvatures ranging between 25-35 o were divided into three groups of 20 teeth each. based on pre-instrumentation radiographs that assessed the angle and the radius of can...