the culture media optimization is an inevitable part of upstream process development in therapeutic monoclonal antibodies (mabs) production. the quality by design (qbd) approach defines the assured quality of the final product through the development stage. an important step in qbd is determination of the main quality attributes. during the media optimization, some of the main quality attribute...

The culture media optimization is an inevitable part of upstream process development in therapeutic monoclonal antibodies (mAbs) production. The quality by design (QbD) approach defines the assured quality of the final product through the development stage. An important step in QbD is determination of the main quality attributes. During the media optimization, some of the main quality attribute...

the effect of different carbon sources on bacterial cellulose production by gluconacetobacter xylinus (ptcc 1734) and two newly isolated strains (from vinegar) under static culture conditions was studied. the production of bacterial cellulose was examined in modified hestrin-shramm medium by replacing d-glucose with other carbon sources. the results showed that the yield and characteristics of ...

halophilic and halotolerant microorganisms are good candidates for decolorization of azo dyeswhich are routinely used in the dyeing process in textile industries. in this paper, theoptimization of biological decolorization of synthetic dye solutions containing remazol black bby the previously isolated halophilic bacterium halomonas sp. d2 is investigated. in a primaryinvestigation using a one-f...

Signal optimization is affected during radio links between a transmitter and a receiver located in adjacent material media with differing optical densities. The optimization is carried out via the automated control theory method. The radio signal obtained after the optimization is coordinated with the two media's electrical characteristics simultaneously; and this enables low power and small an...

In this paper, we give a short overview of our current research on abstractions and concepts needed to achieve the long-term objective of realizing a genuine universal media server. Such a media server is supposed to support a wide range of non-trivial multimedia applications in an approximately optimal manner. Focusing on the handling of raw media data, we argue that the traditional data indep...

We demonstrate steady-state focusing of coherent light through dynamic scattering media. The phase of an incident beam is controlled both spatially and temporally using a reflective, 1020-segment MEMS spatial light modulator, using a coordinate descent optimization technique. We achieve focal intensity enhancement of between 5 and 400 for dynamic media with speckle decorrelation time constants ...