Medetomidine (0.03 mg/kg) and medetomidine/ketamine (0.05/5.0 and 0.025/2.5 mg/kg), administered by intravenous injection, were evaluated for short-term immobilization of wild-caught variable flying foxes (Pteropus hypomelanus). Medetomidine alone produced incomplete chemical restraint and a stressful, prolonged induction. Both ketamine/medetomidine doses produced a smooth induction and complet...

The effects of premedicating cats with saline, xylazine or medetomidine before anaesthetising them with propofol-sevoflurane were compared. Twenty-four cats were randomly assigned to three groups of eight to receive either 0.25 ml of saline, 0.50 mg/kg of xylazine or 0.02 mg/kg of medetomidine intravenously, and anaesthesia was induced with propofol and maintained with sevoflurane. Medetomidine...

A new anti-fouling drug, medetomidine, was tested to determine if it reduced the burying speed of a freshwater alien-invasive bivalve species, Corbicula fluminea. Corbicula are known to damage underwater structures and must be managed with chemical paints. The burying speeds of Corbicula were measured both before and after exposure to two different concentrations of medetomidine. The burying sp...

BACKGROUND To identify a pharmacological agent that can selectively activate cardiac vagus nerve for potential use in vagal activation therapy against heart failure, the effects of medetomidine on autonomic nerve activities in both the heart and stomach were examined. METHODS AND RESULTS In anesthetized rabbits, microdialysis probes were implanted into both the right atrial and gastric walls....

Marine biofouling, growth on submerged surfaces, is a problem for the commercial shipping industry but also for recreational boat owners. It leads to increased fuel consumption, loss of maneuverability and is a source of invasive species. The common solution to avoid biofouling is to use antifouling paints containing biocides which hinder the fouling organisms from growing on the ship hull. Med...

We investigated the effects of combinations of the alpha 2-agonist medetomidine with either ketamine or propofol for their overall quality of anaesthesia, including the possible concomitant changes in respiratory and circulatory function in New Zealand White rabbits. Medetomidine was administered at 0.35 mg/kg, intramuscularly. Following sedation, ketamine (5 mg/kg) or propofol (2 and 3 mg/kg) ...

Editor’s key points † The combined effect of ketamine and medetomidine on cognition and apoptosis was studied in mice. † No differences were seen between groups in terms of spatial memory or apoptosis. † Hyperlocomotive activity in mice receiving ketamine was attenuated by medetomidine. † Co-administration of ketamine and medetomidine may be clinically useful. Background. Ketamine is increasing...

The aim of this study was to determine the effects of intramuscular injection of medetomidine on intra-renal arteriesresistive and pulsatility indices by duplex Doppler ultrasonographyin clinically normal adult domestic shorthair cats. For this purpose, twenty-six neutered adult healthy domestic shorthair cats (13 females and 13 males) were evaluated. B-mode, color Doppler and pulsed wave Doppl...

We chemically restrained free-ranging coyotes (Canis latrans), red foxes (Vulpes vulpes), and raccoons (Procyon lotor) using medetomidine antagonized by atipamezole. All coyotes and 80% of red foxes were sedated with mean 6 standard deviation doses of 0.12 6 0.02 mg/kg and 0.14 6 0.02 mg/kg medetomidine, respectively. Seventy-seven percent of raccoons were sedated with 0.21 6 0.05 mg/kg medetom...

This study was performed to determine the optimal reversal dosage of atipamezole on medetomidine-ketamine combination anesthesia. The subject rabbits were divided into five groups (n=5/group), and all were anesthetized with intravenous medetomidine (0.35 mg/kg) and ketamine (5 mg/kg). Atipamezole was administered intravenously 35 min after administration of the medetomidine-ketamine mixture, at...