We introduce the concept of distance mean-regular graph, which can be seen as a generalization of both vertex-transitive and distance-regular graphs. A graph Γ = (V,E) with diameter D is distance meanregular when, for given u ∈ V , the averages of the intersection numbers ai(u, v), bi(u, v), and ci(u, v) (defined as usual), computed over all vertices v at distance i = 0, 1, . . . , D from u, do...