In our previous work we proposed Model-Driven Performance Engineering (MDPE) as a methodology to integrate performance engineering into the model-driven engineering process. MDPE enables domain experts, who generally lack performance expertise, to profit from performance engineering by automating the performance analysis process using model transformations. A crucial part of this automated proc...

The Medical Data and Picture Exchange platform (MDPE), as a teleradiology system, facilitates the exchange of digital medical imaging data among authorized users. It features extensive support of the DICOM standard including networking functions. Since MDPE is designed as a web service, security and confidentiality of data and communication pose an outstanding challenge. To comply with demands ...

Late identification of performance problems can lead to significant additional development costs. Hence, it is necessary to address performance in several development phases by performing a performance engineering process. We show that Model-Driven Engineering (MDE) specifics can be utilised for performance engineering. Therefore, we propose a process combining MDE and performance engineering c...

in the present work, high temperature tensile properties of medium density polyethylene (mdpe) and its nanocomposites are investigated. for this purpose mdpe reinforced with different weight percentages of nano-sized calcium (2, 5, 10) are produced by compression moulding method. tensile tests have been carried out at different temperatures, i.e. 30, 60, 90c using thermomechanical analysis (tm...

BACKGROUND Available alfentanil pharmacokinetic (PK) sets for target-controlled infusion (TCI) were derived from populations with normal BMI. The performance and accuracy of the models devised by Maitre and colleagues and Scott and colleagues were evaluated in a population including morbidly obese patients. METHODS Alfentanil TCI using Maitre and colleagues' model was administered to 10 obese...

We gained experiences in implementing rule based model transformations within an industrial case study called Model-Driven Performance Engineering (MDPE). Similar to other MDE scenarios, these transformations have been implemented via multiple transformation steps interconnected in an automated model transformation chain. In this short paper, we use the MDPE case study to demonstrate reasons fo...

Gentamicin shows large variations in half-life and volume of distribution (Vd) within and between individuals. Thus, monitoring and accurately predicting serum levels are required to optimize effectiveness and minimize toxicity. Currently, two population pharmacokinetic models are applied for predicting gentamicin doses in adults. For endocarditis patients the optimal model is unknown. We aimed...

In computer vision tasks, it frequently happens that gross noise occupies the absolute majority of the data. Most robust estimators can tolerate no more than 50% gross errors. In this article, we propose a highly robust estimator, called MDPE (Maximum Density Power Estimator), employing density estimation and density gradient estimation techniques in the residual space. This estimator can toler...

BACKGROUND About 98% of plasma propofol is bound to albumin. We investigated if severe hypoalbuminaemia may affect the accuracy of a target-controlled infusion (TCI) device, the Diprifusor, during sedation in critically ill patients. METHODS Ten critically ill hypoalbuminaemic patients (<24 g litre(-1)) and 10 critically ill normoalbuminaemic patients (>32 g litre(-1)) were included in this s...