نتایج جستجو برای: mdco

تعداد نتایج: 23  

2014
Herman J Kempen Dorota B Schranz Bela F Asztalos James Otvos Elias Jeyarajah Denise Drazul-Schrader Heidi L Collins Steven J Adelman Peter L J Wijngaard

MDCO-216 is a complex of dimeric ApoA-IMilano and palmitoyl oleoyl phosphatidylcholine (POPC), previously shown to reduce atherosclerotic plaque burden. Here we studied the effect of incubation of human plasma or serum with MDCO-216 on cholesterol efflux capacity from J774 cells, on prebeta-1 high density lipoprotein (prebeta-1 HDL) and on HDL size assessed by proton nuclear magnetic resonance ...

2016
D.G. Kallend J.A.A. Reijers S.E. Bellibas A. Bobillier H. Kempen J. Burggraaf M. Moerland P.L.J. Wijngaard

AIMS Apolipoprotein A-1 (ApoA-1), based on epidemiology, is inversely associated with cardiovascular (CV) events. Human carriers of the ApoA-1 Milano variant have a reduced incidence of CV disease. Regression of atherosclerotic plaque burden was previously observed on intravascular ultrasound (IVUS) with ETC-216, a predecessor of MDCO-216. MDCO-216, a complex of dimeric ApoA-1 Milano and 1-palm...

2013
Herman J Kempen Daniel Bellus Oleg Fedorov Silke Nicklisch Panagis Filippakopoulos Sarah Picaud Stefan Knapp

Expression and secretion of apolipoprotein A-I (apoA-I) by cultured liver cells can be markedly stimulated by triazolodiazepines (TZDs). It has been shown previously that the thieno-TZD Ro 11-1464 increases plasma levels of apoA-I and in vivomacrophage reverse cholesterol transport in mice. However, these effects were only seen at high doses, at which the compound could act on central benzodiaz...

ژورنال: علوم آب و خاک 2015
خلیلی مقدم, بیژن, رهنما, مجید, عبدلی, سیما,

Quantitative measurement of aeolian dust may help properly monitor and control the wind erosion. The aim of this study was to evaluate the efficiencies of four aeolian dust samplers including the modified Wilson and Cooke sampler (MWAC), cyclone dust sampler with cone (CDSC), cyclone dust sampler (CDS), and marble dust collector (MDCO) in comparison with the big spring number eight sampler (BSN...

2005
S. R. ABDOLLAHI S. M. FAKHRAIE M. KAMAREI

We have designed and implemented a flexible programmable multi-channel digitally-controlled oscillator (MDCO) on an Altera MAX9400 Complex Programmable Logic Device (CPLD) chip. Based on elaborate experiments with the system, we have developed techniques by which to improve its linearity, resolution and stability in an improved MDCO design. This new architecture is programmable to oscillate fro...

ژورنال: :علوم آب و خاک 0
سیما عبدلی s. abdoli dept. of soil sci., agric. and natur. resour. univ. of khuzestan, khuzestan, iran.گروه علوم خاک، دانشگاه کشاورزی و منابع طبیعی رامین خوزستان بیژن خلیلی مقدم b. khalili moghadam dept. of soil sci., agric. and natur. resour. univ. of khuzestan, khuzestan, iran.گروه علوم خاک، دانشگاه کشاورزی و منابع طبیعی رامین خوزستان مجید رهنما m. rahnama dept. of mechanical eng. of biosystem, agric. and natur. resour. univ. of khuzestan, khuzestan, iran.گروه مکانیک ماشین های کشاورزی، دانشگاه کشاورزی و منابع طبیعی رامین خوزستان

اندازه گیری کمی ریزگرد ها کمک شایانی در منشاء یابی و کنترل فرسایش بادی می نماید. هدف از انجام این پژوهش ارزیابی کارایی تله اصلاح شده ویلسون و کوک (mwac)، تله رسوب گیر دورانی با مخروط (cdsc)، تله رسوب گیر دورانی بدون مخروط (cds) و تله رسوب گیر تیله ای (mdco) در مقایسه با نمونه گیر bsne در سرعت های گوناگون با اندازه ذرات متفاوت بود. بدین منظور نمونه گیر های mwac،bsne وmdco شبیه سازی و دو تله رسوب...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2016
Herman J Kempen Bela F Asztalos Matthijs Moerland Elias Jeyarajah James Otvos David G Kallend S Eralp Bellibas Peter L J Wijngaard

OBJECTIVE To determine effects of single ascending doses of MDCO-216 on high-density lipoprotein (HDL) subfractions in relation to changes in cholesterol efflux capacity in healthy volunteers and in patients with stable angina pectoris. APPROACH AND RESULTS Doses of 5- (in volunteers only), 10-, 20-, 30-, and 40-mg/kg MDCO-216 were infused during 2 hours, and plasma and serum were collected d...

Journal: :European heart journal 2013
Mihaly Medvegy Agnes Szekula Katalin Diófalvi Robert Kirschner

HDL delipidation, whole HDL particle infusion with CER-001, MDCO-216, or CSL-112, and gene therapy using HDL-related proteins such as Apo A-I. Further clinical evaluation of direct infusion of mutant (Apo A-1 Milano) or wild-type Apo A-1, linked with a phospholipid carrier, appears warranted since their vascular benefits have been repeatedly demonstrated in animal models and small clinical stud...

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