background: angiogenesis, which is required for embryonic development and many physiological events, plays crucial role in many pathological conditions such as tumor growth and metastasis. recent studies indicate anticancer and antitumor properties of saffron against human cancers. many processes are affected by electromagnetic field (emf) and its effect on proliferation and gene expression wer...

Objective(s):Multidrug resistance (MDR) of cancer cells is a major obstacle to successful chemotherapy. Overexpression of breast cancer resistance protein (BCRP) is one of the major causes of MDR. In addition, it has been shown that PI3K/Akt signaling pathway involves in drug resistance. Therefore, we evaluated the effects of novel approaches including siRNA directed against BCRP and targeted t...

objective(s):multidrug resistance (mdr) of cancer cells is a major obstacle to successful chemotherapy. overexpression of breast cancer resistance protein (bcrp) is one of the major causes of mdr. in addition, it has been shown that pi3k/akt signaling pathway involves in drug resistance. therefore, we evaluated the effects of novel approaches including sirna directed against bcrp and targeted t...

Introduction: Hydroxyapatite nanoparticles inhibit the growth of various cancer cells. The inhibitory effect of these nanoparticles on breast cancer cells of mcf7 has also been reported. However, no studies have been done on the effect of the hydroxyapatite nanoparticles on the radiation sensitivities of the MCF7 cell Line. Our goal in this study is to investigate the effect of...

We examined the role of multidrug resistance protein (MRP) 1 (ABCC1) in the emergence of mitoxantrone (MX) cross-resistance in a MCF7 breast cancer cell line selected for resistance to etoposide. The resistant cell line, MCF7/VP, expresses high levels of MRP1, whereas the parental cell line, MCF7/WT, does not. MCF7/VP cells are 6-10-fold cross-resistant to MX when compared with MCF7/WT cells. D...

Accumulating evidence indicates that breast cancer is caused by cancer stem cells and cure of breast cancer requires eradication of breast cancer stem cells. Previous studies with leukemia stem cells have shown that NF-jB pathway is important for leukemia stem cell survival. In this study, by using MCF7 sphere cells as model of breast cancer stem-like cells, we evaluated the effect of NF-jB pat...

The development of resistance to the antiestrogen tamoxifen occurs in a high percentage of initially responsive patients. We have developed a new model in which to investigate acquired resistance to triphenylethylenes. A stepwise in vitro selection of the hormone-independent human breast cancer variant MCF-7/LCC1 against 4-hydroxytamoxifen produced a stable resistant population designated MCF7/...

Senescence-induced therapy has been improved to increase its cytotoxicity and reduce the resistance of breast cancer cells chemotherapy agents. An example a potential senescence-inducing agent is black cumin oil (BCO) because one major compounds, α-pinene, can induce senescent cells. This study aims explore activity BCO in HER2-overexpressing (MCF7/HER2). The yield obtained from hydro-distillat...

The aim of the study was to investigate the effect of selected polyphenols: gallic acid (GA) and epigallocatechin gallate (EGCG) on matrix metalloproteinase (MMP-2 and MMP-9) activity in multidrug resistant (MDR) human breast adenocarcinoma cells: MCF7/DOX cells and obtained recently in our laboratory MCF7/DOX500 cells by the permanent selection of MCF7/DOX cells with 500 nM doxorubicin (DOX). ...