this study was conducted to examine if allergic contact dermatitis (acd) alters the expression of mmps in human dermal fibroblasts. fibroblasts are the primary source for mmp and matrix production in skin. mmps are known to involve in a number of physiological and pathological processes. some published data indicated a gelatinase-like activity in acute and chronic phases of allergic contact der...

background serum apoptotic cytokeratine 18 neoepitope m30 (ck-18 m30) and matrix metalloproteinase 2 (mmp-2) have been popular markers for detecting liver fibrosis in recent years. ck-18 is a major intermediate filament protein in liver cells and one of the most prominent substrates of caspases during hepatocyte apoptosis. mmp-2 plays an important role in tissue remodeling and repairing process...

results genotype frequencies of g/a in fertile and infertile men were significantly different (χ2 = 4.16, df = 1, p = 0.041). genotype frequencies of g/g and a/ain fertile and infertile men were not significantly different (χ2 = 3.32, df = 1, p = 0.068 and χ2 = 0.521, df = 1, p = 0.47, respectively). the risk of infertility was 1.43 folds higher in individuals with the a/a genotype compared to ...

background: breast cancer is one of the most common cancers in the world, particularly in iran. there are many genomic and molecular factors that cause the occurrence of breast cancer. many markers are associated with tumor invasiveness. matrix metalloproteinase includes a family of zinc-dependent endopeptidases that degrade various components of the extracellular matrix and basement membrane. ...

objective: diabetes plays an important role in the progression of tissue damage. influencing factors of the cellular matrix can lead to changes in the structure and function of tissues or their failure. herbal consumption can be effective in reducing tissue failure. the aim of the this study is to research the effect portulaca oleracea seeds on the levels of matrix metalloproteinase 2, 9 and ti...

background: beta-adrenergic blocking agents have been broadly used for treatment of many cardiovascular diseases such as arterial hypertension and ischemic heart failure. anti-tumoral, anti-inflammatory and anti-angiogenesis effects of propranolol (a non-selective beta-adrenergic blocker) have been shown. angiogenesis (replenish of the pre-existing vascular networks) plays a critical role in so...

there are emerging data on novel tumor markers such as matrix metalloproteinase-2 (mmp-2 or gelatinase-a), which play a key role in tissue invasion and metastasis. we designed an investigation to assess the usefulness of mmp-2 activity as compared to prostate specific antigen (psa) in cancer staging process. we have analyzed the circulating form of mmp-2 in serum samples of patients suffering f...

breast cancer  patients  are  susceptible to  infections such  as  candidiasis. due  to  the importance and the role of matrix metalloproteinases (mmp) in breast cancer progression and its correlation with tumor metastasis, we analyzed the serum level of mmps -2, -3, -9 and tissue inhibitor of matrix metalloproteinase-1 (timp-1) in breast cancer bearing mice in the presence of systemic candida ...