down syndrome (ds), trisomy 21, is the most common chromosomal syndrome that affects one in 600-800 live births. the advanced maternal age is the only well known risk factor to cause ds. our study revealed that many young mothers produced ds children than advanced age mothers in india. a total of 150 suspected ds cases were investigated cytogenetically. randomly selected 200 healthy families in...

Background:Hospitalization of the newborn infant can cause depression crisis and severely undermine the attainment and realization of maternal role in a primipara. The neonate’s maternal grandmother can provide the support needed to help the primipara avoid or overcome the ensuing problems. Aim: This study aimed to investigate the effect of empowerment of grandmothers on depression and maternal...

OBJECTIVE To use Nath et al.'s (1991) conceptual model of adolescent parenting to examine the relationship between resiliency factors measured shortly after delivery and maternal parenting behavior at 6 months. METHOD We recruited 181 first-time, adolescent African American mothers at delivery. Data on resiliency factors (maturity, self-esteem, and mother-grandmother relationships) were colle...

BACKGROUND There are animal data that indicate that prenatal environmental exposures have sex-specific effects on subsequent generations. In humans, an increase in birthweight has been reported if the maternal grandmother had smoked in the pregnancy giving rise to the mother. Here we assess whether prenatal exposure of either parent to cigarette smoke has a sex-specific effect on the grandchild...

BACKGROUND A WOMAN OF REPRODUCTIVE AGE OFTEN HARBORS A SMALL NUMBER OF FOREIGN CELLS, REFERRED TO AS MICROCHIMERISM: a preexisting population of cells acquired during fetal life from her own mother, and newly acquired populations from her pregnancies. An intriguing question is whether the population of cells from her own mother can influence either maternal health during pregnancy and/or the ne...

The Wiskott-Aldrich syndrome (WAS) is a severe X-linked disorder characterized classically by thrombocytopenia, immunodeficiency, and eczema. The phenotype observed in this syndrome is caused by mutation in the WAS gene. Peripheral blood DNAs were isolated from an 18-month-old boy with WAS and his mother, maternal uncle, and maternal grandmother. Genetic analysis for the detection of a mutation...

Objectives: To study whether advanced maternal age and maternal grandmother age are associated with increased risk of Down syndrome siblings in a group of Jordanian families. Methods: This study was conducted on 127 confirmed Down syndrome cases with the age range of 18 weeks gestation to 15 years old, which were referred between the period of 2005-2008 for cytogenetic analysis at the Cytogenti...

Maternal grandmothers residing in 3-generation households often provide care and support to their grandchildren. However, the implications of grandmother coresidence and involvement for adolescent adjustment have been neglected in the South African literature. This study examined whether the involvement of maternal grandmothers who coreside with grandchildren and their parents differed from tha...

AIMS Cardiovascular diseases (CVDs) have been related to low birth weight, suggesting the foetal environment may program future risk. Alternatively, common genetic factors for both low birth weight and CVD could explain such associations. We investigated associations between offspring birth weight and paternal and maternal cardiovascular mortality and offspring birth weight and cardiovascular m...