We propose a method to analyze family-based samples together with unrelated cases and controls. The method builds on the idea of matched case-control analysis using conditional logistic regression (CLR). For each trio within the family, a case (the proband) and matched pseudo-controls are constructed, based upon the transmitted and untransmitted alleles. Unrelated controls, matched by genetic a...

a 1:1 matched case-control study of calves under 1 month of age was carried out by weekly visits to 7 dairy farms in mashhad from may 2008 to october 2008. fecal samples were collected from a total of 112 calves with clinical signs of diarrhea and from 112 matched animals without clinical signs of diarrhea as assessed by a scoring system. the samples were investigated for the presence of rotavi...

This paper considers the problem of estimating the spectrum of real-valued signals. We propose real-valued versions of the Capon and the APES spectral estimators. The estimators are derived as members of the Matched-Filterbank (MAFI) estimator class as introduced in [1]. Furthermore, we show that the real-valued estimators will be unbiased, whereas the complex-valued estimators will have a (sli...

Perturbation of a steadily propagating crack with a straight edge is solved using the method of matched asymptotic expansions (MAE). This provides a simplified analysis in which the inner and outer solutions are governed by distinct mechanics. The inner solution contains the explicit perturbation and is governed by a quasi-static equation. The outer solution determines the radiation of energy a...

'National Cancer Institute, Biometric Research Branch, DCTD, Executive Plaza North, Room 739, 6130 Executive Boulevard, MSC 7434, Bethesda, Maryland 20892-7434, U.S.A. 2National Cancer Institute, Biometry Research Group, DCP, Executive Plaza North, Room 344, 6130 Executive Boulevard, Bethesda, Maryland 20892, U.S.A. 3F0x Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 1911...

background: the traditional methods of studying the gene-environment interactions need a control group. however, the selection of an appropriate control group has been associated with problems. therefore, new methods, such as case-only design, have been created to study such interactions. the objective of this study was to compare the case-only and case-control designs using data from patients ...

The problem of designing finite-length discrete-time matched filters is considered for situations in which exact knowledge of the input signal and/or noise characteristics is not available. Such situations arise in many applications due to channel distortion, incoherencies, nonlinear effects, and other modeling uncertainties. In such cases it is often of interest to design a minimax robust matc...

Background: The traditional methods of studying the gene-environment interactions need a control group. However, the selection of an appropriate control group has been associated with problems. Therefore, new methods, such as case-only design, have been created to study such interactions. The objective of this study was to compare the case-only and case-control designs using data from patients ...