نتایج جستجو برای: maroteaux lamy syndrome

تعداد نتایج: 622119  

Journal: :American journal of medical genetics 1981
D L Van Dyke A L Fluharty I A Schafer L J Shapiro H Kihara L Weiss

Maroteaux-Lamy syndrome exhibits deficient activity of the enzyme arylsulfatase-B in cultured skin fibroblasts. Prenatal diagnosis was successfully attempted in two pregnancies of a consanguineous Chaldean couple whose first child is affected with Maroteaux-Lamy syndrome. In both instances, deficient arylsulfatase-B activity was observed in amniotic fluid cell cultures, and the diagnosis was co...

2017
Farnoosh Mohammadi Iman Tavakoli

The role of the genetic disorders in maxillofacial manifestations is well documented. Maroteaux Lamy syndrome (mucopolysaccharidosis VI) is a metabolic and chromosomal abnormality which involving disturbances in mucopolysaccharide metabolism and storage of acid mucopolysaccharide in various tissues. The main factor for Maroteaux Lamy syndrome is defi ciency of arylsulfatase B. Deposition of muc...

2014
Harry Pachajoa Carlos Armando Rodriguez

Mucopolysaccharidosis type VI or Maroteaux Lamy syndrome is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B, the clinical features include short stature, hepatosplenomegaly, dysostosis multiplex, stiff joints, corneal clouding, cardiac abnormalities, and facial dysmorphism, with intelligence usually normal. We present evidence of the possible exi...

Journal: :Postgraduate medical journal 1992
T H Marwick B Bastian C F Hughes B P Bailey

The case is reported of a young woman with the Maroteaux-Lamy syndrome (mucopolysaccharidosis type VI) who presented with rapidly progressive dyspnoea due to mitral stenosis. Mitral valve replacement was performed and the appearance of the valve was typical of mucopolysaccharide infiltration. Dyspnoea in patients with the Maroteaux-Lamy syndrome may be due primarily to cardiac valve involvement...

Journal: :Journal of medical genetics 1978
H R Taylor F C Hollows J J Hopwood E F Robertson

The first 2 reported cases of a mucopolysaccharidosis occurring in an Australian aboriginal family are presented. Though these children had the characteristic morphological features of the Hurler syndrome, enzyme assay of cultured fibroblasts showed normal levels of alpha-L-iduronidase and decreased activity of arylsulphatase B. Thus, they represented the Hurler syndrome clinically, while they...

Journal: :Case Reports in Ophthalmological Medicine 2019

Journal: :Circulation 1992
C T Tan H V Schaff F A Miller W D Edwards P S Karnes

BACKGROUND Maroteaux-Lamy syndrome is a lysosomal storage disease of mucopolysaccharide metabolism (MPS type VI) that may involve the mitral and aortic valves. Affected patients have other skeletal and oropharyngeal malformations that complicate anesthetic and surgical management. METHODS AND RESULTS The present report describes the clinical, echocardiographic, and pathological findings in fo...

Journal: :American journal of medical genetics. Part A 2013
Marion Brands Jorine Roelants Ronald de Krijger Ad Bogers Arnold Reuser Ans van der Ploeg Wim Helbing

Maroteaux-Lamy syndrome (mucopolysaccharidosis type VI) is a rare lysosomal storage disorder in which the pathologic storage of glycosaminoglycans in various tissues can lead to severe symptoms, including cardiomyopathy. We report on a child with Maroteaux-Lamy syndrome whose cardiac condition deteriorated and eventually led to cardiac failure at the age of 7 years due to severe mitral regurgit...

2012
Cem Sayilgan Lale Yuceyar Sedat Akbas Hulya Erolcay

Mucopolysaccharidoses (MPSs) are a group of metabolic diseases transmitted in an autosomal recessive fashion. MPSs are due to deficiencies of the specific enzymes responsible for the catabolism of dermatan sulfate, heparin sulfate, and keratan sulfate, resulting in the accumulation of glycosaminoglycans (GAGs). MPSs have a chronic, progressive course with multisystemic involvement. The incidenc...

2013
Rajeev Puri Arpita Saxena Awak Mittal Zia Arshad Yogita Dwivedi Trilok Chand Apurva Mittal Archna Agrawal Jay Prakash Sathiyanarayanan Pilendran

Pycnodysostosis (the Toulouse-Lautrec syndrome) is a rare autosomal-recessive disorder of osteoclast dysfunction. This disorder was first described by Maroteaux and Lamy in 1962. We describe anaesthetic management of a 35-year-old female having pyknodysostosis with fracture shaft left femur with anticipated difficult intubation. Therefore, spinal anesthesia was planned for her fracture fixation...

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