Background MAPIT is a three-arm randomized controlled trial assessing in-person Motivational Interviewing (MI) condition versus computerized (MAPIT) condition versus control. Our goal is to estimate the costs and cost-effectiveness for the study. We present preliminary findings on the startup costs and the implementation costs of the two intervention conditions, MI and MAPIT. To our knowledge, ...

Bisulfite sequencing is a widely-used technique for examining cytosine DNA methylation at nucleotide resolution along single DNA strands. Probing with cytosine DNA methyltransferases followed by bisulfite sequencing (MAPit) is an effective technique for mapping protein-DNA interactions. Here, MAPit methylation footprinting with M.CviPI, a GC methyltransferase we previously cloned and characteri...

Epistasis, commonly defined as the interaction between multiple genes, is an important genetic component underlying phenotypic variation. Many statistical methods have been developed to model and identify epistatic interactions between genetic variants. However, because of the large combinatorial search space of interactions, most epistasis mapping methods face enormous computational challenges...

A “less than truckload” (LTL) network organises the transport of small shipping volumes by truck between given depots. To be cost-efficient it is necessary to bundle and unbundle goods on their way, using depots as so-called hubs. Our aim is to develop a strategic plan which is cost-optimal for given average shipping volumes. We consider transshipment and transport costs; to give a realistic es...

A firm’s strategic choices are represented in its business model. The choices made here can be evaluated by understanding the impact of those choices on performance such as adoption rate etc. However, the business model choices are affected by the market situation in which the firm operates. Thus, there is a link between market conditions, business model choices, and performance. This link was ...

A business model represents the decision space for strategic options of a firm. These options are determined by the market situation in which the firm operates. Among these options the firm makes its strategic decisions which are evaluated by the firm’s performance in the market measured by business values. Thus, there is a link between market conditions, business model choices, and performance...

Deregulation of gene expression, a hallmark of cancer, is caused by both genetic and epigenetic mechanisms. The rapid accumulation of epigenome maps of various cancers suggests a new avenue of research, namely integrating epigenomic data with other types of omic data for cancer diagnosis, prognosis, and biomarker discovery. We introduce the MAPIT algorithm (Multi Analyte Pathway Inference Tool)...

Design patterns provide a means to reuse proven solutions during development, but also to identify good practices during analysis. These are particularly relevant in complex and critical software, such as is the case of ubiquitous and pervasive systems. Model Driven Engineering (MDE) presents a solution for this problem, with the usage of high level models. As part of an effort to develop appro...

Human tumors are comprised of heterogeneous cell populations that display diverse molecular and phenotypic features. To examine the extent to which epigenetic differences contribute to intratumoral cellular heterogeneity, we have developed a high-throughput method, termed MAPit-patch. The method uses multiplexed amplification of targeted sequences from submicrogram quantities of genomic DNA fol...