Convenient and simple procedures for the synthesis of functionalized Quinoxaline derivatives were developed via one-pot four-component reaction of o-aminoanilin, acetylenic ester, and malonyl dichloride in the presence of K2 CO3 as effective base catalyst. These compounds widely are used in various industries like paint, pharmaceutical and medicine. Quinoxaline derivatives are also part of anti...

The extensive pharmacological applications of the pyrazole-based compounds stimulated us to synthesize highly functionalized, pyrazolylmalonyl diisothiocyanate derivative (2) via treating 2-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)malonyl dichloride (1) with ammonium thiocyanate in acetonitrile at room temperature. 2 was subsequently conducted a double molar ratio different nitrogen nucleophile...

ante by carboxylic acid would result if the equilibrium of Reaction 3 were significantly toward R(CHz), CO-S-CoA or if the latter disappeared in secondary reactions. In practice, acetylCoA was incubated with enzyme fractions with and without added carboxylic acids under the conditions described in Table I. At the end of the incubation period, 0.1 volume of 30% metaphosphoric acid was added, the...

In general, ethylene/1,3-butadiene copolymerizations provides copolymers possessing both pendant vinyls and vinylenes as olefinic moieties. We, at MCI, studied the substituent effects of C2-symmetric zirconocene complexes, rac-[Me2Si(Indenyl’)2]ZrCl2 (Indenyl’ = generic substituted indenyl), after activation on the ratio of the pendant vinyls and vinylenes of the resultant copolymers. Complexes...

Six new titanocene compounds have been isolated and characterised. These compounds were synthesised from their fulvene precursors using Super Hydride (LiBEt3H) followed by transmetallation with titanium tetrachloride to yield the corresponding titanocene dichloride derivatives. These complexes are bis-[((1-methyl-3-diethylaminomethyl)indol-2-yl)methylcyclopentadienyl] titanium (IV) dichloride (...

We systematically assessed the cytotoxic effects of five metallocene dichlorides containing vanadium (vanadocene dichloride), titanium (titanocene dichloride), zirconium (zircodocene dichloride), molybdenum (molybdocene dichloride), and hafnium (hafnocene dichloride) as the central metal atom and 19 other vanadocene complexes. These compounds were tested against the human testicular cancer cell...

The goal of this study was to test the relationship between malonyl-CoA concentration and its turnover measured in isolated rat hearts perfused with NaH(13)CO(3). This turnover is a direct measurement of the flux of acetyl-CoA carboxylation in the intact heart. It also reflects the rate of malonyl-CoA decarboxylation, i.e. the only known fate of malonyl-CoA in the heart. Conditions were selecte...

Ethylarsine dichloride was used during WW I as a chemical warfare agent. Residues of this chemical warfare agent and its metabolites are still present today and continue to contaminate soil and water. A gas Chromatographic method for the detection and determination of ethylarsine dichloride is shown. Six dithiols were tested as possible derivatization reagents for ethylarsine dichloride. With s...

BACKGROUND Bone metastases are associated with increased morbidity and poor prognosis in breast cancer patients. Radium-223 dichloride is a calcium mimetic that localizes to bone, providing targeted therapy for skeletal metastasis. METHODS We investigated the mode of action of radium-223 dichloride using breast cancer cell, osteoclast, and osteoblast cultures as well as a mouse model of breas...

BACKGROUND Malonyl-coenzyme A (CoA) is an important biosynthetic precursor in vivo. Although Escherichia coli is a useful organism for biosynthetic applications, its malonyl-CoA level is too low. RESULTS To identify strains with the best potential for enhanced malonyl-CoA production, we developed a whole-cell biosensor for rapidly reporting intracellular malonyl-CoA concentrations. The biosen...