Chronic hypoxia induces pulmonary hypertension and vascular remodeling, which are clinically relevant to patients with chronic obstructive pulmonary disease (COPD) associated with a decreased level of nitric oxide (NO). Oxidative stress and inflammation play important roles in the pathophysiological processes in COPD. We examined the hypothesis that daily administration of melatonin (10 mg/kg) ...

Thymol and Butylated hydroxytoluene (BHT) were tested for their ability to inhibit carbon tetrachloride (CCl4)-induced lipid peroxidation in mice liver. To achieve this purpose, four groups of mice were tested, GP I: Animals served as normal control, GP II: Animals injected i.p. with a single dose of CCl4 (0.5 ml/kg B.W), GP III and IV: Animals pretreated by oral administration of thymol or BHT...

Cadmium (Cd) is widely used in some industries and emitted from fossil fuels. It a heavy metal with number of side effects, including hepatotoxicity. Resveratrol (Rs) considered an important polyphenol, which secondary plant metabolite has the ability to scavenge free radicals. The study was designed evaluate effects resveratrol on Cd, induced hepatotoxicity, by assessment histopathological bio...

Hyperhomocysteinemia (Hhcy) has been associated with pathological and stressful conditions and is a risk factor for cardiovascular disease (CVD). The aim of this study was to evaluate the correlation between plasma homocysteine (hcy) and lipid peroxidation in patient with CVD. This study was carried out on 40 patients with CVD as well as 15 healthy volunteers of comparable age and gender as con...

The present study investigated the cytogenetic and testicular damage induced by the antiepileptic drug, sodium valporate (SVP) in albino rats and the effect of saffron aqueous extracts. Treating rats with SVP caused a significant increase in the chromosomal aberrations either structural or numerical and decreased the mitotic index. Besides, animals administered SVP showed DNA damage appeared in...

Article type: Original article Objective(s): The present study was undertaken to determine the effects of acute exposure to malathion on oxidative stress and cytotoxic potential of anticholinesterase insecticide, malathion in reproductive toxicology of adolescent male mice. Materials and Methods: Thirty two adolescent male mice at pubertal age were treated with 500 mg/kg body weight (BW) of mal...

The aim of the present study was to evaluate the change in corneal protein and oxidative stress state after using photodynamic therapy (PDT) for treatment of experimental corneal neovascularization (NV) with benzoporphyrin derivative (BPD). One group was considered as control (N = 10 eyes), corneal NV was induced in 25 New Zealand male rabbits (N = 50 eyes) after placing silk sutures in the cor...

Cinnamon is used to flavor most foods in Arabian countries. The aim of this study was to evaluate the medicinal importance, reflecting an important trend in research. The hepatoprotective activity of aqueous and ethanolic extracts of cinnamon was investigated against carbon tetrachloride (CC1(4)) induced lipid peroxidation and hepatic injury in rats. The elevated serum AST and ALT enzymatic act...

BACKGROUND Thermal injury is associated with several biochemical and histopathological alteration in tissue. Analysis of these objective parameters in research and clinical field are common to determine healing rate of burn wound. Negative pressure wound therapy has been achieved wide success in treating chronic wounds. This study determines superficial burn wound healing with intermittent nega...

BACKGROUND The relationship between the high activity of aldose reductase (AR) and diabetic cataract formation has been previously investigated. The purpose of the present study was to determine the preventing effect of melatonin on streptozotocin (STZ)-induced diabetic cataract in rats. METHODS 34 adult healthy male Sprague-Dawely rats were divided into four groups. Diabetic control and diab...