Magnesium (Mg) has been developed as a drug with various clinical uses. Mg is a key cation in physiological processes, and the homeostasis of this cation is crucial for the normal function of body organs. Magnesium sulfate (MgSO4) is a mineral pharmaceutical preparation of magnesium that is used as a neuroprotective agent. One rationale for the frequent use of MgSO4 in critical care is the high...

based on a number of studies, magnesium sulfate (mgso4) given after a diffuse axonal injury has gained attention as a useful neuroprotective agent .the present study was conducted to examine if magnesium sulfate has a therapeutic efficacy and safety in patients with a severe diffuse axonal injury. adult patients admitted within 1 hour of a closed traumatic brain injury (tbi) with a severe diffu...

Background: Several studies have shown that administration of magnesium sulfate prolongs the bleeding time. Objective: To investigate such effects in pregnant women in Shiraz, southern Iran.  Methods:This study was conducted on 30 pregnant women aged between 18 and 32 yrs, with a gestational age of 20 to 37 weeks, who presented to Hafez and Zeynabiyeh Emergency Units affiliated to Shiraz Univer...

Background: Lactate Dehydrogenase (LDH) is most often measured to evaluate tissue damage. Magnesium sulfate is used for seizure therapy and as prophylaxis for eclampsia and preeclampsia, worldwide. The objectives were: 1. To assess serum LDH levels as a biochemical marker to reflect the severity of pre-eclampsia/eclampsia 2. To study the alterations in serum magnesium levels in eclampsia patien...

OBJECTIVES To determine the response of nebulized magnesium sulfate on the lung function of acetylcholine-induced asthma children. METHODS Three hundred and thirty children of asthma with positive bronchial provocation test were randomly divided into three groups: magnesium sulfate, albuterol, and a combination of magnesium sulfate and albuterol. Lung function was compared between the three g...

Magnesium is the fourth most abundant cation in the body and the second most abundant cation in intracellular fluid. Magnesium plays an important role in numerous biological functions. In the present study we investigated the effect of magnesium sulfate (MgSO4) on histological abnormalities induced by bile duct ligation in male Wistar rats. The effects of 28-day oral administration of MgSO4 (at...

The objective of our study is to quantitatively examine the available evidence regarding the efficacy and side effects of magnesium sulfate for acute tocolysis (from randomized trials) compared with placebo and beta-agonist agents. Randomized trials comparing magnesium sulfate with placebo or beta-agonists for tocolysis were identified with a MEDLINE-based search and was supplemented by a searc...

Objective This study aimed to estimate the association between total and ionized magnesium, and the changes in serum magnesium and calcium levels in patients with preterm labor during magnesium sulfate (MgSO4) administration. Methods The study population included 64 women who were candidates for intravenous MgSO4 treatment for preterm labor. Serial blood samples were taken and measured total ...

Background: Previous studies have shown that magnesium sulfate (MgSO4) administered in a patient with a diffuse axonal injury (DAI) can serve as a useful neuroprotective agent. The present study was conducted to examine whether magnesium sulfate has a therapeutic efficacy and safety in patients with a severe diffuse axonal injury. Methods: Adult patients admitted within 1 hour of a closed Traum...

BACKGROUND Diabetic nephropathy is a serious complication of T1D (type one diabetes mellitus). Persistent hyperglycemia and subsequent hypomagnesemia is believed to develop kidney damage by activation of oxidative stress. We conducted this study to investigate the renoprotective effect of magnesium sulfate (MgSO4) on renal histopathology and oxidative stress in diabetic rats. METHODS The stud...